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COL1A1 Rabbit Polyclonal Antibody (CAB1352)

SKU:
CAB1352
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 4 Anti-COL1A1 Antibody CAB1352
  • Cell Biology Antibodies 4 Anti-COL1A1 Antibody CAB1352
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:COL1A1 Rabbit Polyclonal Antibody
SKU:CAB1352
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1151-1250 of human Collagen I/COL1A1 (NP_000079.2).
Sequence:GKDG LNGL PGPI GPPG PRGR TGDA GPVG PPGP PGPP GPPG PPSA GFDF SFLP QPPQ EKAH DGGR YYRA DDAN VVRD RDLE VDTT LKSL SQQI ENIR SPEG
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IHC-P,1:50 - 1:200
Synonyms:OI1; OI2; OI3; OI4; EDSC; CAFYD; EDSARTH1; Collagen I/COL1A1
Positive Sample:Mouse bone
Conjugate:Unconjugated
Cellular Localization:Secreted, extracellular matrix, extracellular space.
Calculated MW:139kDa
Observed MW:220kDa

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Purification Method:Affinity purification
Gene ID:1277
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse bone using Collagen I/COL1A1 Rabbit pAb(CAB1352) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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