Anti-Furin Antibody (CAB5043)

Product Name:	Furin Rabbit mAb
Product Code:	CAB5043
Size:	20uL, 50uL, 100uL
Synonyms:	FUR, PACE, PCSK3, SPC1
Applications:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human Furin

Applications:	WB
Recommended Dilutions:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	HeLa, HT-29, A-549, Mouse brain

Immunogen:	A synthesized peptide derived from human Furin
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	5045
Uniprot:	P09958
Cellular Location:	Cell membrane, Golgi apparatus, Single-pass type I membrane protein, trans-Golgi network membrane
Calculated MW:	87kDa
Observed MW:	90KDa

UniProt Protein Function:	FURIN: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. Furin subfamily.
UniProt Protein Details:	Protein type:EC 3.4.21.75; Vesicle; Protease; Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q26.1 Cellular Component: Golgi membrane; extracellular space; trans-Golgi network transport vesicle; cell surface; membrane; Golgi lumen; integral to membrane; plasma membrane; trans-Golgi network; lipid raft Molecular Function:peptidase activity; serine-type endopeptidase inhibitor activity; protease binding; metal ion binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding; peptide binding Biological Process: extracellular matrix organization and biogenesis; viral reproduction; nerve growth factor receptor signaling pathway; peptide hormone processing; regulation of signal transduction; pathogenesis; viral infectious cycle; proteolysis; positive regulation of membrane protein ectodomain proteolysis; peptide biosynthetic process; nerve growth factor processing; extracellular matrix disassembly; transforming growth factor beta receptor signaling pathway; regulation of endopeptidase activity; negative regulation of nerve growth factor production; secretion by cell; Notch signaling pathway; signal peptide processing; virus assembly; post-translational protein modification; peptidyl-glutamic acid carboxylation; nerve growth factor production; negative regulation of transforming growth factor-beta1 production; collagen catabolic process; cell proliferation; cellular protein metabolic process; viral protein processing; protein processing; regulation of protein catabolic process; negative regulation of low-density lipoprotein receptor catabolic process
NCBI Summary:	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Code:	P09958
NCBI GenInfo Identifier:	120611
NCBI Gene ID:	5045
NCBI Accession:	P09958.2
UniProt Secondary Accession:	P09958,Q14336, Q6LBS3, Q9UCZ5,
UniProt Related Accession:	P09958
Molecular Weight:	86,678 Da
NCBI Full Name:	Furin
NCBI Synonym Full Names:	furin (paired basic amino acid cleaving enzyme)
NCBI Official Symbol:	FURIN
NCBI Official Synonym Symbols:	FUR; PACE; SPC1; PCSK3
NCBI Protein Information:	furin; FES upstream region; dibasic processing enzyme; furin, membrane associated receptor protein; proprotein convertase subtilisin/kexin type 3; paired basic amino acid residue-cleaving enzyme
UniProt Protein Name:	Furin
UniProt Synonym Protein Names:	Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE
Protein Family:	Furin
UniProt Gene Name:	FURIN
UniProt Entry Name:	FURIN_HUMAN