Human MAT2A Recombinant Protein (RPPB1925)
- SKU:
- RPPB1925
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P31153
- Research Area:
- Enzymes
Description
| Product Name: | Human MAT2A Recombinant Protein |
| Product Code: | RPPB1925 |
| Size: | 20µg |
| Species: | Human |
| Target: | MAT2A |
| Synonyms: | MATA2, MATII, SAMS2, MAT-2A, S-adenosylmethionine synthetase isoform type-2, AdoMet synthetase 2, Methionine adenosyltransferase 2, Methionine adenosyltransferase II, MAT2A, AMS2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MAT2A solution (1mg/ml) contains 20mM Tris pH-8 & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY |
MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer. NF-kappa B and AP-1 are necessary for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha. Up-regulation of MAT2A provides growth improvement and s-adenosylmethionine and methylthioadenosine thus can block mitogenic signaling in colon cancer cells. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
MAT2A Human Recombinant fused with His tag (20 a.a.) at C-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 415 amino acids and having a molecular mass of 45.8 kDa.The MAT2A is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MAT2A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Belongs to the AdoMet synthase family. |
| UniProt Protein Details: | Protein type:Transferase; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6 Chromosomal Location of Human Ortholog: 2p11.2 Cellular Component: cytosol; methionine adenosyltransferase complex Molecular Function:methionine adenosyltransferase activity; protein binding Biological Process: methylation; S-adenosylmethionine biosynthetic process |
| NCBI Summary: | The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011] |
| UniProt Code: | P31153 |
| NCBI GenInfo Identifier: | 400245 |
| NCBI Gene ID: | 4144 |
| NCBI Accession: | P31153.1 |
| UniProt Secondary Accession: | P31153,Q53SP5, A8K511, B4DN45, D6W5L1, |
| UniProt Related Accession: | P31153 |
| Molecular Weight: | 32,965 Da |
| NCBI Full Name: | S-adenosylmethionine synthase isoform type-2 |
| NCBI Synonym Full Names: | methionine adenosyltransferase 2A |
| NCBI Official Symbol: | MAT2A�� |
| NCBI Official Synonym Symbols: | MATA2; MATII; SAMS2�� |
| NCBI Protein Information: | S-adenosylmethionine synthase isoform type-2 |
| UniProt Protein Name: | S-adenosylmethionine synthase isoform type-2 |
| UniProt Synonym Protein Names: | Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-II |
| Protein Family: | S-adenosylmethionine synthase |
| UniProt Gene Name: | MAT2A�� |
| UniProt Entry Name: | METK2_HUMAN |
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