Description
| Product Name: | Mouse CD11a monoclonal antibody (PE) |
| Product Code: | AGIM0270 |
| Size: | 500 µL |
| Reactivity: | Mouse |
| Clone: | M17/4 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG2a |
| Host Species: | Rat |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P20701 |
| Background: | CD11a is a 180 kD glycoprotein, also known as ?±L integrin, LFA-1 ?±, Ly-15, or Ly-21. It is a member of the integrin family, primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes. In association with CD18, the CD11a/CD18 complex forms LFA-1. CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). |
| UniProt Protein Function: | ITGAL: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Belongs to the integrin alpha chain family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Cell surface Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cell surface; membrane; plasma membrane; immunological synapse; intercellular junction; integrin complex; external side of plasma membrane Molecular Function:protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; ICAM-3 receptor activity; cell adhesion molecule binding Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; regulation of immune response; cell-matrix adhesion; activated T cell proliferation; positive regulation of calcium-mediated signaling; signal transduction; receptor clustering; heterophilic cell adhesion; leukocyte adhesion; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of T cell proliferation; inflammatory response; blood coagulation; cell adhesion; cell motility; leukocyte migration |
| NCBI Summary: | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20701 |
| NCBI GenInfo Identifier: | 88911345 |
| NCBI Gene ID: | 3683 |
| NCBI Accession: | P20701.3 |
| UniProt Secondary Accession: | P20701,O43746, Q45H73, Q96HB1, Q9UBC8, |
| UniProt Related Accession: | P20701 |
| Molecular Weight: | |
| NCBI Full Name: | Integrin alpha-L |
| NCBI Synonym Full Names: | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
| NCBI Official Symbol: | ITGALÂ Â |
| NCBI Official Synonym Symbols: | CD11A; LFA-1; LFA1AÂ Â |
| NCBI Protein Information: | integrin alpha-L; LFA-1A; LFA-1 alpha; integrin gene promoter; CD11 antigen-like family member A; lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide |
| UniProt Protein Name: | Integrin alpha-L |
| UniProt Synonym Protein Names: | CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD_antigen: CD11a |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGALÂ Â |
| UniProt Entry Name: | ITAL_HUMAN |
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