The Mouse Polycystin-1 (PKD1) ELISA Kit is specifically designed for the accurate measurement of Polycystin-1 levels in mouse serum, plasma, and cell culture supernatants. This kit offers high sensitivity and specificity, ensuring precise and reliable results for a variety of research applications.Polycystin-1 is a key protein involved in the regulation of cell proliferation and differentiation, as well as cell-cell and cell-matrix interactions. Mutations in the PKD1 gene have been linked to the development of polycystic kidney disease (PKD), a serious genetic disorder characterized by the formation of fluid-filled cysts in the kidneys.
By accurately quantifying Polycystin-1 levels, researchers can gain valuable insights into the pathophysiology of PKD and potentially discover new therapeutic targets for the treatment of this debilitating condition. The Mouse Polycystin-1 (PKD1) ELISA Kit is a valuable tool for investigating the role of Polycystin-1 in health and disease, and for advancing our understanding of PKD.
Product Name:
Mouse Polycystin-1 (Pkd1) ELISA Kit
SKU:
MOEB2450
Size:
96T
Target:
Mouse Polycystin-1 (Pkd1)
Synonyms:
Autosomal dominant polycystic kidney disease 1 protein homolog
Assay Type:
Sandwich
Detection Method:
ELISA
Reactivity:
Mouse
Detection Range:
0.78-50ng/mL
Sensitivity:
0.39ng/mL
Intra CV:
9.1%
Inter CV:
11.1%
Linearity:
Sample
1:2
1:4
1:8
1:16
Serum(N=5)
107-117%
110-120%
101-110%
103-113%
EDTA Plasma(N=5)
90-98%
92-102%
86-98%
108-120%
Heparin Plasma(N=5)
100-110%
107-117%
101-111%
100-110%
Recovery:
Sample Type
Average(%)
Recovery Range(%)
Serum
99
93-105
Plasma
101
95-107
Function:
Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.
Uniprot:
O08852
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
