Anti-PROX1 Antibody (CAB9047)

SKU:
CAB9047
€129 - €349

Description

Technical Manual

Anti-PROX1 Antibody

Product Name:Anti-PROX1 Antibody
Product SKU:CAB9047
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Immunogen:A synthesized peptide derived from human PROX1
Sequence:

Email for sequence

Gene ID:5629
Swiss Prot:Q92786
Synonyms:
Calculated MW:95kDa
Observed MW:90KDa
Reactivity:Human, Mouse, Rat
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry
Positive Samples:SH-SY5Y, Mouse liver, Rat liver
Cellular Location:

Product Images

Anti-PROX1 Antibody (CAB9047)

Western blot - PROX1 Rabbit mAb (CAB9047)

Uniprot Information

UniProt Protein Function:PROX1: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons. Belongs to the Prospero homeobox family.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; nucleus

Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor binding; protein binding; DBD domain binding; DNA binding; LBD domain binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; lens development in camera-type eye; circadian rhythm; neural tube development; positive regulation of cyclin-dependent protein kinase activity; ventricular cardiac myofibril development; muscle thin filament assembly; atrial cardiac muscle morphogenesis; positive regulation of transcription, DNA-dependent; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; olfactory placode formation; negative regulation of cell proliferation; venous blood vessel morphogenesis; pancreas development; positive regulation of cell proliferation; lymphangiogenesis; ventricular cardiac muscle morphogenesis; kidney development; response to nutrient levels; dentate gyrus development; negative regulation of transcription factor activity; positive regulation of cell cycle; liver development; regulation of circadian rhythm; cerebellar granule cell differentiation; dorsal spinal cord development; negative regulation of viral genome replication; regulation of gene expression; otic placode formation; embryonic retina morphogenesis in camera-type eye; positive regulation of endothelial cell proliferation; optic placode formation involved in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; retina morphogenesis in camera-type eye; lung development

NCBI Summary:The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
UniProt Code:Q92786
NCBI GenInfo Identifier:85702224
NCBI Gene ID:5629
NCBI Accession:Q92786.2
UniProt Secondary Accession:Q92786,Q5SW76, Q8TB91, A6NK29, A8K2B1,
UniProt Related Accession:Q92786
Molecular Weight:737
NCBI Full Name:Prospero homeobox protein 1
NCBI Synonym Full Names:prospero homeobox 1
NCBI Official Symbol:PROX1
NCBI Protein Information:prospero homeobox protein 1; prospero-related homeobox 1; homeobox prospero-like protein PROX1
UniProt Protein Name:Prospero homeobox protein 1
UniProt Synonym Protein Names:Homeobox prospero-like protein PROX1; PROX-1
Protein Family:Prospero homeobox protein
UniProt Gene Name:PROX1
UniProt Entry Name:PROX1_HUMAN
View AllClose

Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
View AllClose