Recombinant Human ALK/ACVRL1 Protein (Fc Tag) (RPES4895)

SKU:
RPES4895
€41

Description

ELISA Kit Technical Manual

Recombinant Human ALK/ACVRL1 Protein (Fc Tag)

Background:Activin Receptor-Like Kinase 1 (ALK) is a type I cell-surface receptor for the TGF-?superfamily of ligands. ALK has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. The mutations of ALK are associated with Rendu-Osler-Weber syndrome 2, this suggests ACVRL1 is associated with blood vessel development and repair.
Name:Recombinant Human ALK/ACVRL1 Protein (Fc Tag)
Size:10µg
Assay Genie SKU:RPES4895
Synonyms:Serine/Threonine-Protein Kinase Receptor R3; SKR3; Activin Receptor-Like Kinase 1; ALK; TGF-B Superfamily Receptor Type I; TSR-I; ACVRL1; ACVRLK1; ALK1;HHT;HHT2;ORW2;SKR3
Species:Human
Expression host:Human Cells
Sequence:Asp22-Gln118
Accession:P37023
Mol Mass:37.6 kDa
AP Mol Mass:50-60 kDa
Tag:C-Fc
Purity:> 90% as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per ?g as determined by the LAL method.
Storage:Lyophilized protein should be stored at < -20'C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of PBS,pH 7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:ALK1: a kinase of the STKR family. A type I cell-surface receptor for the TGF-beta superfamily of ligands including Activin A. Highly expressed in human placenta and lung. Deficiency causes hemorrhagic telangiectasia type 2 also known as Rendu-Osler-Weber syndrome 2.
UniProt Protein Details:

Protein type:EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function:activin binding; activin receptor activity, type I; ATP binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I

Biological Process: angiogenesis; blood circulation; blood vessel endothelial cell proliferation during sprouting angiogenesis; blood vessel maturation; blood vessel remodeling; BMP signaling pathway; lymphangiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell adhesion; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of focal adhesion formation; positive regulation of BMP signaling pathway; positive regulation of chondrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of blood pressure; regulation of blood vessel endothelial cell migration; regulation of DNA replication; regulation of endothelial cell proliferation; regulation of transcription, DNA-dependent; signal transduction; transforming growth factor beta receptor signaling pathway; wound healing, spreading of epidermal cells

Disease: Telangiectasia, Hereditary Hemorrhagic, Type 2

NCBI Summary:This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
UniProt Code:P37023
NCBI GenInfo Identifier:3915750
NCBI Gene ID:94
NCBI Accession:P37023.2
UniProt Secondary Accession:P37023,A6NGA8,
UniProt Related Accession:P37023
Molecular Weight:56,124 Da
NCBI Full Name:Serine/threonine-protein kinase receptor R3
NCBI Synonym Full Names:activin A receptor like type 1
NCBI Official Symbol:ACVRL1  
NCBI Official Synonym Symbols:HHT; ALK1; HHT2; ORW2; SKR3; ALK; TSR-I; ACVRLK1  
NCBI Protein Information:serine/threonine-protein kinase receptor R3
UniProt Protein Name:Serine/threonine-protein kinase receptor R3
UniProt Synonym Protein Names:Activin receptor-like kinase 1; ALK; TGF-B superfamily receptor type I; TSR-I
Protein Family:Serine/threonine-protein kinase haspin
UniProt Gene Name:ACVRL1  
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Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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