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Apolipoprotein C-II/APOC2 Recombinant Protein (RPES2867)

SKU:
RPES2867
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

ELISA Kit Technical Manual

Recombinant Human Apolipoprotein C-II/APOC2 Protein (His Tag)

Background:APOC2 activates the lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. APOC2 is component of the very low density lipoprotein (VLDL) fraction in plasma. It is also an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B) which characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.
Name:Recombinant Human Apolipoprotein C-II/APOC2 Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES2867
Synonyms:Apolipoprotein C-II; Apolipoprotein C2; APC2 and APOC2
Species:Human
Expression host:E.coli
Sequence:Met 1-Glu82
Accession:P02655
Mol Mass:10.0 kDa
AP Mol Mass:14 kDa
Tag:C-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mMPB,150mM NaCL,30%glycerol,pH7.2.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: chylomicron; early endosome; extracellular region; extracellular space

Molecular Function:lipase inhibitor activity; lipid binding; phospholipase activator activity; phospholipase binding; protein homodimerization activity

Biological Process: cholesterol efflux; cholesterol homeostasis; lipoprotein metabolic process; negative regulation of cholesterol transport; negative regulation of lipid metabolic process; negative regulation of receptor-mediated endocytosis; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; retinoid metabolic process; reverse cholesterol transport

Disease: Apolipoprotein C-ii Deficiency

NCBI Summary:This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
UniProt Code:P02655
NCBI GenInfo Identifier:114022
NCBI Gene ID:344
NCBI Accession:P02655.1
UniProt Secondary Accession:P02655,Q9BS39, Q9UDE3, Q9UNK3, C0JYY4,
UniProt Related Accession:P02655
Molecular Weight:11,284 Da
NCBI Full Name:Apolipoprotein C-II
NCBI Synonym Full Names:apolipoprotein C2
NCBI Official Symbol:APOC2
NCBI Official Synonym Symbols:APO-CII; APOC-II
NCBI Protein Information:apolipoprotein C-II
UniProt Protein Name:Apolipoprotein C-II
UniProt Synonym Protein Names:Apolipoprotein C2
Protein Family:Apolipoprotein
UniProt Gene Name:APOC2
UniProt Entry Name:APOC2_HUMAN