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Human B7-H4/VTCN1 Recombinant Protein (RPES4341)

SKU:
RPES4341
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology
€255
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Description

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Human B7-H4/VTCN1 Recombinant Protein

B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains; a 21 aa transmembrane segment; and a 2 aa cytoplasmic tail. It is widely expressed; including in kidney; liver; lung; pancreas; placenta; prostate; spleen; testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation; proliferation; cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages; plays an important role; together with regulatory T-cells (Treg); in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.