Plexin domain-containing protein 1; also known as tumor endothelial marker 3; tumor endothelial marker 7 and PLXDC1 and TEM3; is a secreted; cytoplasm and single-pass type I membrane protein which belongs to the plexin family. PLXDC1 / TEM3 is detected in endothelial cells from colorectal cancer; and in endothelial cells from primary cancers of the lung; liver; pancreas; breast and brain. It is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. PLXDC1 / TEM3 is not detectable in endothelial cells from normal tissue. PLXDC1 / TEM3 plays a critical role in endothelial cell capillary morphogenesis. PLXDC1 / TEM3 may play a significant role in the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs). PLXDC1 / TEM3 may be a molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy (PDR). PLXDC1 / TEM3 interacts with NID1. It may also interact with CTTN.
Product Name:
Human IL17RC Recombinant Protein (RPES0152)
Product Code:
RPES0152
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
IL17-RL,IL17RL,UNQ6118/PRO20040/PRO38901
Accession:
NP_116121.2
Sequence:
Met 1-Ala 454
Fusion tag:
C-Fc
Activity:
Measured by its ability to bind with recombinant human IL17A-His in a functional ELISA.2. Measured by its ability to bind with recombinant human 17A in a functional ELISA.
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the extracellular domain of human IL17RC isoform 3 (NP_116121.2) (Met 1-Ala 454) was fused with the Fc region of human IgG1 at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
75.3 kDa
AP Mol Mass:
100-120 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
