Recombinant Human Kallikrein 4/KLK4 Protein (His Tag) (RPES2848)

SKU:
RPES2848
€196

Description

ELISA Kit Technical Manual

Recombinant Human Kallikrein 4/KLK4 Protein (His Tag)

Background:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen members of the Kallikrein subfamily located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
Name:Recombinant Human Kallikrein 4/KLK4 Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES2848
Synonyms:Kallikrein-4; Enamel Matrix Serine Proteinase 1; Kallikrein-Like Protein 1; KLK-L1; Prostase; Serine Protease 17; KLK4; EMSP1; PRSS17; PSTS;AI2A1;ARM1;EMSP;kallikrein;KLK-L1
Species:Human
Expression host:Human Cells
Sequence:Ser27-Ser254
Accession:Q9Y5K2
Mol Mass:25.4 kDa
AP Mol Mass:30 kDa
Tag:C-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:KLK4: Involved in enamel formation. Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1). AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase S1 family. Kallikrein subfamily.
UniProt Protein Details:

Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region

Molecular Function:serine-type peptidase activity; serine-type endopeptidase activity; metal ion binding

Biological Process: extracellular matrix disassembly; protein catabolic process; proteolysis

Disease: Amelogenesis Imperfecta, Hypomaturation Type, Iia1

NCBI Summary:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]
UniProt Code:Q9Y5K2
NCBI GenInfo Identifier:317373372
NCBI Gene ID:9622
NCBI Accession:Q9Y5K2.2
UniProt Secondary Accession:Q9Y5K2,Q4VB16, Q96RU5, Q9GZL6, Q9UBJ6,
UniProt Related Accession:Q9Y5K2
Molecular Weight:254
NCBI Full Name:Kallikrein-4
NCBI Synonym Full Names:kallikrein-related peptidase 4
NCBI Official Symbol:KLK4
NCBI Official Synonym Symbols:ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein
NCBI Protein Information:kallikrein-4; prostase; serine protease 17; kallikrein-like protein 1; androgen-regulated message 1; enamel matrix serine protease 1; enamel matrix serine proteinase 1
UniProt Protein Name:Kallikrein-4
UniProt Synonym Protein Names:Enamel matrix serine proteinase 1; Kallikrein-like protein 1; KLK-L1; Prostase; Serine protease 17
Protein Family:Kallikrein
UniProt Gene Name:KLK4
UniProt Entry Name:KLK4_HUMAN
View AllClose

Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
View AllClose