Description
| Product Name: | Recombinant Human PRTN3 Protein (His Tag) |
| SKU: | RPES8254 |
| Size: | 20μg |
| Tag: | C-His |
| Reactivity: | Human |
| Expression Host: | stable cell line |
| Accession: | P24158 |
| Sequence: | Met1-Pro256 |
| Calculated Molecular Weight: | 28 kDa |
| Observed Molecular Weight: | 35 kDa |
| Synonyms: | ACPA, AGP 7, AGP7, AGP7 serine proteinase, Azurophil Granule Protein 7, C ANCA, C ANCA antigen, C-ANCA antigen, CANCA, EC 3.4.21.76, Leukocyte proteinase 3, MBN, MBT, MBT WEGENER AUTOANTIGEN, Myeloblastin, Neutrophil proteinase 4, NP 4, NP-4, NP4, P29, PR 3, PR-3, PR3, Proteinase 3 |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro. By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
