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Human S100B Recombinant Protein (RPES4387)

SKU:
RPES4387
Product Type:
Recombinant Protein
Species:
Human
$226
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Description

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Human S100B Recombinant Protein

S100-B; is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment; differentiation; and brain construction. S100-B has neuroprotective effects; but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage; which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS; and the astrocytes are the major cells producing S100-B protein in gray matter; as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop; enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition; S100-B; which is also present in human melanocytes; is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.