The SNX10 Polyclonal Antibody (PACO60448) is a powerful tool for researchers studying SNX10, a crucial protein involved in intracellular trafficking and sorting. This antibody, generated in rabbits, exhibits high specificity and sensitivity for SNX10 in human samples, making it ideal for a variety of applications, including Western blot analysis. By binding to SNX10, this antibody enables the detection and analysis of SNX10 in different cell types, offering valuable insights into its function in cellular processes.
SNX10 is a key player in endosomal sorting and recycling pathways, contributing to the maintenance of cell homeostasis and proper protein localization. Dysfunction of SNX10 has been linked to various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular health. Research on SNX10 is essential for understanding its role in disease pathology and developing targeted therapies to correct any abnormalities associated with SNX10 dysregulation.
Antibody Name:
SNX10 Antibody (PACO60448)
Antibody SKU:
PACO60448
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Sorting nexin-10 protein (124-201AA)
IHC image of PACO60448 diluted at 1:300 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.
Synonyms:
Sorting nexin-10, SNX10
UniProt Protein Function:
SNX10: May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis. Overexpression causes formation of huge vacuoles. Belongs to the sorting nexin family.Chromosomal Location of Human Ortholog: 7p15.2Cellular Component: centrosome; endoplasmic reticulum; nucleusMolecular Function: ATPase binding; phosphatidylinositol bindingBiological Process: protein transport; endosome organization and biogenesis; vesicle organization and biogenesis; cilium biogenesis; endocytosis; osteoclast differentiationDisease: Osteopetrosis, Autosomal Recessive 8
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
