UniProt Protein Function: | AP-2 epsilon: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation. Belongs to the AP-2 family.Protein type: DNA-binding; Transcription factorChromosomal Location of Human Ortholog: 1p34.3Cellular Component: nucleusMolecular Function: protein homodimerization activity; protein heterodimerization activityBiological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; anatomical structure development; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q6VUC0 |
NCBI GenInfo Identifier: | 194353976 |
NCBI Gene ID: | 339488 |
NCBI Accession: | NP_848643.2 |
UniProt Secondary Accession: | Q6VUC0,Q8IW12 |
UniProt Related Accession: | Q6VUC0 |
Molecular Weight: | 46,212 Da |
NCBI Full Name: | transcription factor AP-2-epsilon |
NCBI Synonym Full Names: | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) |
NCBI Official Symbol: | TFAP2EÂ Â |
NCBI Official Synonym Symbols: | AP2EÂ Â |
NCBI Protein Information: | transcription factor AP-2-epsilon; AP2-epsilon; activating enhancer-binding protein 2-epsilon; adaptor-related protein complex 2, epsilon subunit |
UniProt Protein Name: | Transcription factor AP-2-epsilon |
UniProt Synonym Protein Names: | Activating enhancer-binding protein 2-epsilon |
Protein Family: | Transcription factor |
UniProt Gene Name: | TFAP2EÂ Â |
UniProt Entry Name: | AP2E_HUMAN |