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UBA7 Antibody (PACO30924)

SKU:
PACO30924
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Antibody Name:UBA7 Antibody (PACO30924)
Antibody SKU:PACO30924
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Ubiquitin-like modifier-activating enzyme 7 protein (1-265AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.
Synonyms:Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (D8) (Ubiquitin-activating enzyme E1 homolog), UBA7, UBE1L UBE2
UniProt Protein Function:UBE1L: Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Belongs to the ubiquitin-activating E1 family.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function:ISG15 activating enzyme activity; protein binding; ubiquitin activating enzyme activity; ubiquitin-protein ligase activity

Biological Process: bypass DNA synthesis; ISG15-protein conjugation; modification-dependent protein catabolic process; negative regulation of interferon type I production; protein modification process

NCBI Summary:The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
UniProt Code:P41226
NCBI GenInfo Identifier:215273977
NCBI Gene ID:7318
NCBI Accession:P41226.2
UniProt Secondary Accession:P41226,Q9BRB2,
UniProt Related Accession:P41226
Molecular Weight:111,694 Da
NCBI Full Name:Ubiquitin-like modifier-activating enzyme 7
NCBI Synonym Full Names:ubiquitin like modifier activating enzyme 7
NCBI Official Symbol:UBA7  
NCBI Official Synonym Symbols:D8; UBE2; UBA1B; UBE1L  
NCBI Protein Information:ubiquitin-like modifier-activating enzyme 7
UniProt Protein Name:Ubiquitin-like modifier-activating enzyme 7
UniProt Synonym Protein Names:D8; Ubiquitin-activating enzyme E1 homolog
Protein Family:Ubiquitin-like modifier-activating enzyme
UniProt Gene Name:UBA7  
UniProt Entry Name:UBA7_HUMAN

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