null

Anti-GAD67/GAD1 Antibody (CAB1475)

SKU:
CAB1475
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CPSQ1
GAD
SCP
Research Area:
Neuroscience
$167 - $503
Frequently bought together:

Description

Product Name:GAD67/GAD1 Rabbit mAb
Product Code:CAB1475
Size:20uL, 50uL, 100uL
Synonyms:CPSQ1, GAD, SCP
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GAD67/GAD1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, U-251MG, Mouse lung, Rat lung
Immunogen:A synthesized peptide derived from human GAD67/GAD1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2571
Uniprot:Q99259
Calculated MW:67kDa
Observed MW:70kDa
UniProt Protein Function:GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 4.1.1.15; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Lyase

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: plasma membrane; intracellular; vesicle membrane

Molecular Function:protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding

Biological Process: response to drug; glutamate catabolic process; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; gamma-aminobutyric acid biosynthetic process; protein-pyridoxal-5-phosphate linkage; neurotransmitter biosynthetic process

Disease: Cerebral Palsy, Spastic Quadriplegic, 1

NCBI Summary:This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
UniProt Code:Q99259
NCBI GenInfo Identifier:1352213
NCBI Gene ID:2571
NCBI Accession:Q99259.1
UniProt Secondary Accession:Q99259,Q49AK1, Q53TQ7, Q9BU91, Q9UHH4,
UniProt Related Accession:Q99259
Molecular Weight:66,897 Da
NCBI Full Name:Glutamate decarboxylase 1
NCBI Synonym Full Names:glutamate decarboxylase 1 (brain, 67kDa)
NCBI Official Symbol:GAD1  
NCBI Official Synonym Symbols:GAD; SCP; CPSQ1  
NCBI Protein Information:glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform
UniProt Protein Name:Glutamate decarboxylase 1
UniProt Synonym Protein Names:67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform
Protein Family:Glutamate decarboxylase
UniProt Gene Name:GAD1  
UniProt Entry Name:DCE1_HUMAN

Related Products