Human GSTT2 Recombinant Protein (RPPB1778)
- SKU:
- RPPB1778
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P0CG29
- Research Area:
- Enzymes
Description
| Product Name: | Human GSTT2 Recombinant Protein |
| Product Code: | RPPB1778 |
| Size: | 20µg |
| Species: | Human |
| Target: | GSTT2 |
| Synonyms: | Glutathione S-transferase theta 2, GST class-theta-2, GSTT2B, Glutathione S-transferase theta-2B, EC 2.5.1.18. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GSTT2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS LGKLPTLKDG DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG WHADCIRGTF GIPLWVQVLG PLIGVQVPEE KVERNRTAMD QALQWLEDKF LGDRPFLAGQ QVTLADLMAL EELMQPVALG YELFEGRPRL AAWRGRVEAF LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI ARIP |
GSTT2 belongs to the glutathione s-transferase (GST) family of proteins. There are eight GST proteins families, named alpha, kappa, mu, omega, pi, sigma, theta and zeta. Each one of the GST families has several proteins with different functions throughout the cell. The theta type members GSTT1 and GSTT2 have a 55% aa sequence homology and hold a vital role in human carcinogenesis. The theta genes are structurally similar � each has five exons with identical exon/intron boundaries.
GSTT2 Recombinant produced in�E. coli is a single polypeptide chain containing 264 amino acids (1-244) and having a molecular mass of 29.6kDa.GSTT2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GST2: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity. Belongs to the GST superfamily. Theta family. |
| UniProt Protein Details: | Protein type:EC 2.5.1.18 Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: cytoplasm Molecular Function:glutathione transferase activity Biological Process: glutathione metabolic process |
| NCBI Summary: | The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P0CG29 |
| NCBI GenInfo Identifier: | 300680960 |
| NCBI Gene ID: | 2953 |
| NCBI Accession: | P0CG29.1 |
| UniProt Secondary Accession: | P0CG29,O60665, P30712, Q6IPV7, Q9HD76, |
| UniProt Related Accession: | P0CG29 |
| Molecular Weight: | 27,506 Da |
| NCBI Full Name: | Glutathione S-transferase theta-2 |
| NCBI Synonym Full Names: | glutathione S-transferase theta 2 (gene/pseudogene) |
| NCBI Official Symbol: | GSTT2�� |
| NCBI Protein Information: | glutathione S-transferase theta-2 |
| UniProt Protein Name: | Glutathione S-transferase theta-2 |
| UniProt Synonym Protein Names: | GST class-theta-2 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTT2�� |
| UniProt Entry Name: | GST2_HUMAN |
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