Human KLK5 Recombinant Protein (RPPB1866)
- SKU:
- RPPB1866
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y337
- Research Area:
- Enzymes
Description
| Product Name: | Human KLK5 Recombinant Protein |
| Product Code: | RPPB1866 |
| Size: | 10µg |
| Species: | Human |
| Target: | KLK5 |
| Synonyms: | Kallikrein-5, Kallikrein-like protein 2, KLK-L2, Stratum corneum tryptic enzyme, KLK5, SCTE, UNQ570/PRO1132, KLKL2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | KLK5 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLIINGSDC DMHTQPWQAA LLLRPNQLYC GAVLVHPQWL LTAAHCRKKV FRVRLGHYSL SPVYESGQQM FQGVKSIPHP GYSHPGHSND LMLIKLNRRI RPTKDVRPIN VSSHCPSAGT KCLVSGWGTT KSPQVHFPKV LQCLNISVLS QKRCEDAYPR QIDDTMFCAG DKAGRDSCQG DSGGPVVCNG SLQGLVSWGD YPCARPNRPG VYTNLCKFTK WIQETIQANS HHHHHH |
Kallikrein-5 (KLK5) is a member of the serine protease family of proteolytic enzymes. KLK5 is expressed in various tissues including the salivary gland, stomach, uterus, lung, thymus, prostate, colon, brain, thyroid, and trachea. KLK5 expression is up-regulated by estrogens and progestins. KLK5 is secreted and may be involved in desquamation in the epidermis. Kallikreins which are a subgroup of serine proteases, have distinct physiological functions. Many kallikreins are associated with carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK5 gene is one of the 15 kallikrein subfamily members located in a cluster on chromosome 19.
Kallikrein-5 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 236 amino acids (67-293 a.a.) and having a molecular mass of 26.2kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions).KLK5 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KLK5: May be involved in desquamation. Belongs to the peptidase S1 family. Kallikrein subfamily. |
| UniProt Protein Details: | Protein type:EC 3.4.21.-; Protease; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space Molecular Function:peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity Biological Process: epidermis development; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y337 |
| NCBI GenInfo Identifier: | 296434569 |
| NCBI Gene ID: | 25818 |
| NCBI Accession: | Q9Y337.2 |
| UniProt Secondary Accession: | Q9Y337,Q53ZR3, Q9HBG8, |
| UniProt Related Accession: | Q9Y337 |
| Molecular Weight: | 293 |
| NCBI Full Name: | Kallikrein-5 |
| NCBI Synonym Full Names: | kallikrein-related peptidase 5 |
| NCBI Official Symbol: | KLK5�� |
| NCBI Official Synonym Symbols: | SCTE; KLKL2; KLK-L2�� |
| NCBI Protein Information: | kallikrein-5; kallikrein 5; kallikrein-like protein 2; stratum corneum tryptic enzyme |
| UniProt Protein Name: | Kallikrein-5 |
| UniProt Synonym Protein Names: | Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK5�� |
| UniProt Entry Name: | KLK5_HUMAN |
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