Human PICK1 Recombinant Protein (RPPB2606)
- SKU:
- RPPB2606
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NRD5
- Research Area:
- Enzymes
Description
| Product Name: | Human PICK1 Recombinant Protein |
| Product Code: | RPPB2606 |
| Size: | 10µg |
| Species: | Human |
| Target: | PICK1 |
| Synonyms: | ProteinInteracting With PRKCA 1, PRKCABP, Protein Kinase C-Alpha-Binding Protein, ProteinInteracting With C Kinase 1, Protein Kinase C, Alpha Binding Protein, ProteinInteracting With PRKCA, PRKCA-Binding Protein, PICK, PRKCA-binding protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PICK1 protein solution (0.25mg/ml) containing Phosphatebuffered saline (pH7.4), 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSMFADLDYDIEEDKLGIP TVPGKVTLQK DAQNLIGISI GGGAQYCPCL YIVQVFDNTP AALDGTVAAG DEITGVNGRSIKGKTKVEVA KMIQEVKGEV TIHYNKLQAD PKQGMSLDIV LKKVKHRLVE NMSSGTADAL GLSRAILCNDGLVKRLEELE RTAELYKGMT EHTKNLLRAF YELSQTHRAF GDVFSVIGVR EPQPAASEAF VKFADAHRSIEKFGIRLLKT IKPMLTDLNT YLNKAIPDTR LTIKKYLDVK FEYLSYCLKV KEMDDEEYSC IALGEPLYRVSTGNYEYRLI LRCRQEARAR FSQMRKDVLE KMELLDQKHV QDIVFQLQRL VSTMSKYYND CYAVLRDADVFPIEVDLAHT TLAYGLNQEE FTDGEEEEEE EDTAAGEPSR DTRGAAGPLD KGGSWCDS |
Protein Interacting with PRKCA 1, also known as PICK1 includes a PDZdomain, through which it interacts with protein kinase C, alpha (PRKCA). PICK1performs as an adaptor which binds to and arranges the subcellular localizationof various membrane proteins. PICK1 interacts with multiple glutamate receptorsubtypes, monoamine plasma membrane transporters, in addition to non-voltagegated sodium channels, and might target PRKCA to these membrane proteins and thereforeregulates their distribution as well as function. PICK1 has also been found to performas an anchoring protein which particularly targets PRKCA to mitochondria ina� ligand-specific manner.
PICK1 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 438 amino acids (1-415 a.a) and having a molecularmass of 49.0kDa.�PICK1 is fused to a 23amino acid His-tag at N-terminus & purified by proprietary chromatographictechniques.
| UniProt Protein Function: | PICK1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Ligand, receptor tyrosine kinase; Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: presynaptic membrane; Golgi apparatus; postsynaptic membrane; neuron projection; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; synapse; cell junction Molecular Function:actin filament binding; protein C-terminus binding; identical protein binding; protein domain specific binding; protein binding; enzyme binding; G-protein-coupled receptor binding; protein kinase C binding; metal ion binding; ATPase activity; receptor binding Biological Process: glial cell development; cellular response to glucose starvation; synaptic transmission; DNA methylation during gametogenesis; monoamine transport; positive regulation of receptor internalization; protein kinase C activation; retrograde vesicle-mediated transport, Golgi to ER; DNA methylation during embryonic development; neuronal ion channel clustering; protein amino acid phosphorylation; receptor clustering; protein targeting |
| NCBI Summary: | The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRD5 |
| NCBI GenInfo Identifier: | 22095990 |
| NCBI Gene ID: | 9463 |
| NCBI Accession: | Q9NRD5.2 |
| UniProt Secondary Accession: | Q9NRD5,O95906, B3KS52, |
| UniProt Related Accession: | Q9NRD5 |
| Molecular Weight: | 415 |
| NCBI Full Name: | PRKCA-binding protein |
| NCBI Synonym Full Names: | protein interacting with PRKCA 1 |
| NCBI Official Symbol: | PICK1�� |
| NCBI Official Synonym Symbols: | PICK; PRKCABP�� |
| NCBI Protein Information: | PRKCA-binding protein; protein interacting with C kinase 1; protein kinase C-alpha-binding protein |
| UniProt Protein Name: | PRKCA-binding protein |
| UniProt Synonym Protein Names: | Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein |
| Protein Family: | PRKCA-binding protein |
| UniProt Gene Name: | PICK1�� |
| UniProt Entry Name: | PICK1_HUMAN |
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