The MARCH3 Antibody (PACO02430) is a valuable tool for researchers studying the function of MARCH3, a protein involved in immune regulation and cell surface protein degradation. This polyclonal antibody, produced using advanced techniques, has a high specificity and sensitivity for detecting MARCH3 in various samples.MARCH3 is a member of the membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases, which play a crucial role in regulating the turnover of cell surface receptors and modulating immune responses. The MARCH3 Antibody can be used in Western blot applications to study the expression levels and activity of MARCH3 in different cell types and tissues.
Research on MARCH3 is important for understanding its role in immune cell function, antigen presentation, and immune surveillance. Dysregulation of MARCH3 activity has been implicated in autoimmune diseases, viral infections, and cancer progression. By using the MARCH3 Antibody, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Antibody Name:
MARCH3 Antibody
Antibody SKU:
PACO02430
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat, Monkey
Immunogen:
synthesized peptide derived from the Internal region of human 40605.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MARCH3; RNF173; E3 ubiquitin-protein ligase MARCH3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; MARCH-III; RING finger protein 173
UniProt Protein Function:
MARCH3: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.Protein type: Membrane protein, integral; EC 6.3.2.-; EC 6.3.2.19; Membrane protein, multi-pass; Ubiquitin ligase; Ubiquitin conjugating system; LigaseChromosomal Location of Human Ortholog: 5q23.2Cellular Component: endosome; lysosome
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
