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Human DR6/TNFRSF21 Recombinant Protein (RPES4410)

SKU:
RPES4410
Product Type:
Recombinant Protein
Species:
Human
€132
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Description

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Human DR6/TNFRSF21 Recombinant Protein

Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart; brain; placenta; pancreas; lymph node; thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition; DR6 binds with N-APP; which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF-?.