Human IGF/IGF1 Recombinant Protein (RPES1563)

Product type:
Recombinant Protein
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Human IGF/IGF1 Recombinant Protein

Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are made by proteolytic degradation of inactive precursor proteins, which include the N- and C-terminal propeptide areas. Mature human IGF-I, which consists of 70 amino acids and has a 94 percent homology with mouse IGF-I, has cross-species activity. IGF-1 interacts with the receptors IGF-IR, IGF-IIR, and the insulin receptor, playing an important role in cell cycle progression and cell proliferation. Growth hormone regulates IGF-1 expression. R3 IGF-1, also known as 83 amino acid IGF-1, is a complete human IGF-1 sequence with the Arg (R) at position three replaced for Glu(E), resulting in R3; and a 13 amino acid extension peptide at the N terminus. The R3 IGF-1 was designed to boost biological activity. In vitro, however, R3 IGF-1 is far more powerful than human IGF-I. Human IGF/IGF1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.