Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the?protein kinase superfamily; STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one?protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors; cytokines; ultraviolet light; and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle; heart; and in lesser extent in liver or pancreas.
Product Name:
Human MKK6 Recombinant Protein (RPES1910)
Product Code:
RPES1910
Size:
20µg
Species:
Human
Expressed Host:
Baculovirus-Insect Cells
Synonyms:
MAPKK6,MEK6,MKK6,PRKMK6,SAPKK-3,SAPKK3,MAP2K6
Accession:
P52564-1
Sequence:
Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp
Fusion tag:
N-His & GST
Activity:
The specific activity was determined to be 1250 nmol/min/mg using inactive MAPK14 as substrate.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human MAP2K6 isoform 1 (P52564-1) (Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
