Anti-TBX15/TBX18 Antibody (PACO23730)

Antibody Name:	TBX15/TBX18 Antibody (PACO23730)
Antibody SKU:	PACO23730
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500
Species Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human TBX15/18.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot analysis of extracts from HeLa cells, HUVEC cells and Jurkat cells, using TBX15/18 antibody.
	Immunofluorescence analysis of HeLa cells, using TBX15/18 antibody.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using TBX15/18 antibody.

Background:	Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes By similarity.
Synonyms:	T-box transcription factor TBX15; T-box protein 15; TBX15; TBX14; T-box transcription factor TBX18

UniProt Protein Function:	TBX15: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes. Defects in TBX15 are the cause of Cousin syndrome (COUSS); also known as craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature. Cousin syndrome is defined as pelviscapular dysplasia with epiphyseal abnormalities, congenital dwarfism and facial dysmorphy (frontal bossing, hypertelorism, narrow palpebral fissures, deep set globes, strabismus, low-set posteriory rotated and unusually formed external ears, dysplasia of conchae, small chin, short neck with redundant skin folds, and a low hairline). Intelligence may vary from normal to moderately impaired. Radiographic features comprise aplasia of the body of the scapula, hypoplasia of the iliac bone, humeroradial synosthosis, dislocation of the femoral heads, and moderate brachydactyly. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p11.1 Molecular Function:protein binding Disease: Cousin Syndrome
NCBI Summary:	This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]
UniProt Code:	Q96SF7
NCBI GenInfo Identifier:	59803103
NCBI Gene ID:	6913
NCBI Accession:	Q96SF7.2
UniProt Secondary Accession:	Q96SF7,Q08E76, Q5JT54, Q5T9S7,
UniProt Related Accession:	Q96SF7
Molecular Weight:	54,671 Da
NCBI Full Name:	T-box transcription factor TBX15
NCBI Synonym Full Names:	T-box 15
NCBI Official Symbol:	TBX15
NCBI Official Synonym Symbols:	TBX14
NCBI Protein Information:	T-box transcription factor TBX15
UniProt Protein Name:	T-box transcription factor TBX15
UniProt Synonym Protein Names:	T-box transcription factor TBX14; T-box protein 14
Protein Family:	T-box transcription factor
UniProt Gene Name:	TBX15
UniProt Entry Name:	TBX15_HUMAN

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)