TGF beta Receptor II (TGFBR2) Monoclonal Antibody (CAB19124)
The TGF beta Receptor II (TGFBR2) Monoclonal Antibody (CAB19124) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TGF-beta receptor II is a key player in the TGF-beta signaling pathway, which is known to have diverse roles in immune regulation, tissue development, and tumor suppression. By targeting the TGF-beta receptor II protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an essential tool for studies in immunology, cancer research, and developmental biology.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
TGF beta Receptor II (TGFBR2) Monoclonal Antibody
SKU:
CAB19124
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC0407
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Cell Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
65kDa/67kDa/9kDa
Observed MW:
70-80kDa,90kDa
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Purification Method
Affinity purification
Gene ID
7048
RRID
AB_2862617
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from Hep G2 cells using TGF beta Receptor II Rabbit mAb (CAB19124) at 1:9000 dilution incubated overnight at 4℃. Hep G2 cells were treated by PNGase(1 μL) at 37℃ for 30 minutes. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 30 μg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 45s.
