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Anti-NKX6-1 Antibody (CAB20419)

SKU:
CAB20419
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NKX6A
NKX6.1
$167 - $503
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Description

Product Name:NKX6-1 Rabbit pAb
Product Code:CAB20419
Size:50uL, 100uL
Synonyms:NKX6A, NKX6.1
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human NKX6-1.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, Rat pancreas
Immunogen:Recombinant protein of human NKX6-1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4825
Uniprot:P78426
Calculated MW:37kDa
Observed MW:45KDa/46KDa
UniProt Protein Function:NKX6-1: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals. Protein type: Transcription factor; Cell development/differentiation; DNA-binding Chromosomal Location of Human Ortholog: 4q21.33 Cellular Component: nucleoplasm Molecular Function: chromatin binding Biological Process: response to nicotine; transcription from RNA polymerase II promoter; response to drug; smoothened signaling pathway; positive regulation of insulin secretion; positive regulation of glial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of axon extension; endocrine pancreas development; negative regulation of glial cell differentiation; cell proliferation; organ morphogenesis; detection of glucose; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; pancreas development; oligodendrocyte differentiation; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation
UniProt Protein Details:
NCBI Summary:In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]
UniProt Code:P78426
NCBI GenInfo Identifier:1894911
NCBI Gene ID:4825
NCBI Accession:AAD11962.1
UniProt Secondary Accession:P78426
UniProt Related Accession:P78426
Molecular Weight:37,849 Da
NCBI Full Name:NK homeobox protein
NCBI Synonym Full Names:NK6 homeobox 1
NCBI Official Symbol:NKX6-1  
NCBI Official Synonym Symbols:NKX6A; NKX6.1  
NCBI Protein Information:homeobox protein Nkx-6.1; NK homeobox, family 6, A; homeobox protein NK-6 homolog A; NK homeo box, family 6, member A; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1
UniProt Protein Name:Homeobox protein Nkx-6.1
UniProt Synonym Protein Names:Homeobox protein NK-6 homolog A
Protein Family:Homeobox protein
UniProt Gene Name:NKX6-1  
UniProt Entry Name:NKX61_HUMAN

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