Description

Biotin Anti-Mouse IL-17A Antibody [TC11-18H10.1]

The Biotin Anti-Mouse IL-17A Antibody (TC11-18H10-1) offered by AssayGenie is a valuable tool for researchers studying the role of IL-17A in immune responses and inflammation. This antibody specifically targets mouse IL-17A, a cytokine involved in various immune processes, and is conjugated with biotin for easy detection and analysis.IL-17A is a key player in mediating inflammatory responses and has been implicated in the pathogenesis of several autoimmune diseases and inflammatory conditions. By targeting IL-17A, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.

The Biotin Anti-Mouse IL-17A Antibody is rigorously validated for use in a variety of applications, including immunohistochemistry, flow cytometry, and ELISA, ensuring reliable and reproducible results. Its high specificity and sensitivity make it a valuable tool for investigating the role of IL-17A in immune modulation and disease pathogenesis.Overall, the Biotin Anti-Mouse IL-17A Antibody from AssayGenie is an essential reagent for researchers interested in studying the function of IL-17A in immune-mediated diseases and exploring new avenues for therapeutic interventions.

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Product Title:	Biotin Anti-Mouse IL-17A Antibody [TC11-18H10.1]
SKU:	AGEL3068
Size:	25µg, 100µg
Clone No:	TC11-18H10.1
Synonyms:	Interleukin-17A;IL-17;IL-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA-8;CTLA8;
Host Species:	Rat
Reactivity:	Mouse
Application:	ICFCM

Isotype:	Rat IgG1, κ
Isotype Control:	Biotin Rat IgG1, κ Isotype Control[HRPN]
Form:	Liquid
Conjugation:	Biotin
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	Q62386
Gene ID:	16171
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Biotin Anti-Mouse IL-17A Antibody [TC11-18H10.1] (AGEL3068)

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Description