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Immune Cell 'Bloodhounds': Engineering Metabolite-Sensing Receptors to Infiltrate Solid Tumors
Imagine an elite squad of soldiers sent to neutralize a hidden fortress, only to find themselves wandering aimlessly in a thick, disorienting fog just outside the gates. This is the current reality for many immunotherapy treatments: powerful immune cells are engineered to kill cancer, yet they often fail to even find the tumor. However, a revolutionary new approach is turning these 'lost' cells into biological bloodhounds, capable of sniffing out a tumor's unique chemical scent to lead a precision strike.
Introduction
For decades, the 'holy grail' of oncology has been the development of therapies that can distinguish between healthy tissue and malignant growths with absolute precision. Whil
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25th Mar 2026