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For years, our understanding of cancer focused primarily on the tumor cells themselves and the immune system's response. However, a groundbreaking wave of research is revealing a startling truth: nerves, long considered mere conduits for pain or sensation, are actively co-opted by cancer to build a formidable 'neural shield,' driving resistance to even our most advanced immunotherapies. This paradigm shift is reshaping how we view the battle against cancer. Introduction Immunotherapy has revolutionized cancer treatment, offering unprecedented hope for many patients by harnessing the body's own immune system to fight malignant cells. Yet, a significant challenge remains: a substantial portio …