Description
MIDN Antibody (PACO18224)
The MIDN Polyclonal Antibody (PACO18224) is a valuable tool for researchers studying MIDN, a protein involved in immune modulation and inflammatory responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications.MIDN, also known as immune regulatory molecule, is known for its role in regulating immune responses and maintaining immune homeostasis. It has been implicated in various diseases including autoimmune disorders, cancer, and chronic inflammatory conditions, making it a key target for therapeutic development and research.
By binding to the MIDN protein, this antibody enables detection and analysis of MIDN expression in different cell types, providing essential insights for studies in immunology and cancer research. Understanding the function and regulation of MIDN is crucial for advancing our knowledge of immune system modulation and developing novel treatment strategies for immune-related diseases.
| Antibody Name: | MIDN Antibody (PACO18224) |
| Antibody SKU: | PACO18224 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human MIDN |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lung tissue, Primary antibody: PACO18224(MIDN Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
| Background: | Expression of the midnolin gene is developmentally regulated: it is strongly expressed at the mesencephalon (midbrain) of the embryo in day 12.5 (E12.5) mice. The midnolin encodes a protein of 508 amino acid, (aa), which contains a Ubiquitin-like domain. The intracellular distribution of the midnolin was studied by using midnolin-green fluorescent protein (GFP) fusion proteins. Midnolin was found to be localized in the nucleus and nucleolus, but not in the cytoplasm. The nucleolar localization signal was determined to be a 28aa peptide located at the C-terminal region of the midnolin. May be involved in regulation of genes related to neurogenesis in the nucleolus |
| Synonyms: | Midnolin |
| UniProt Protein Function: | MIDN: May be involved in regulation of genes related to neurogenesis in the nucleolus. |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: nucleolus; cytosol Molecular Function:kinase binding Biological Process: negative regulation of glucokinase activity; negative regulation of insulin secretion |
| UniProt Code: | Q504T8 |
| NCBI GenInfo Identifier: | 296437369 |
| NCBI Gene ID: | 90007 |
| NCBI Accession: | Q504T8.2 |
| UniProt Related Accession: | Q504T8 |
| Molecular Weight: | |
| NCBI Full Name: | Midnolin |
| NCBI Synonym Full Names: | midnolin |
| NCBI Official Symbol: | MIDNÂ Â |
| NCBI Protein Information: | midnolin |
| UniProt Protein Name: | Midnolin |
| UniProt Synonym Protein Names: | Midbrain nucleolar protein |
| Protein Family: | Midnolin |
| UniProt Gene Name: | MIDNÂ Â |
| UniProt Entry Name: | MIDN_HUMAN |
