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Dopamine beta-Hydroxylase Recombinant Protein (RPES5077)

SKU:
RPES5077
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Metabolism
$1,428
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Description

system_update_altDatasheet

Dopamine beta-Hydroxylase Recombinant Protein

Dopamine beta-hydroxylase/DbH oxidoreductase protein is a copper type II, ascorbate-dependent monooxygenase enzyme. The encoded protein, which is present in the adrenal medulla's neuroscretory vesicles and chromaffin granules, converts dopamine to norepinephrine, a hormone and major neurotransmitter of the sympathetic nervous system. Low levels of dopamine beta-hydroxylate is caused by mutations in dopamine beta-hydroxylase/DbH in humans. A deficiency of dopamine beta-hydroxylate is characterised by autonomic and cardiovascular dysfunction, including hypotension and ptosis. Dopamine beta-hydroxylase/DbH polymorphisms might be linked to a variety of mental disorders. Dopamine beta-hydroxylase deficiency and orthostatic hypotension 1 are two diseases linked to DBH.Dopamine beta-Hydroxylase Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.