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Hantavirus, a silent threat lurking in rodent populations, has long posed a significant public health challenge with its severe and often fatal outcomes. For decades, the quest for effective vaccines has been a scientific priority. Now, a new era of vaccine development is dawning, spearheaded by revolutionary mRNA technology, promising unprecedented speed and efficacy in our fight against this elusive pathogen. Introduction Orthohantaviruses, commonly known as hantaviruses, are a group of zoonotic viruses responsible for two severe human diseases: Hemorrhagic Fever with Renal Syndrome (HFRS) in Eurasia and Hantavirus Pulmonary Syndrome (HPS) in the Americas. These illnesses carry high fata …