Interactive Pathway Diagrams
Immune Signalling Pathway Explorer
Explore the immunology behind our In Vivo functional-grade antibody range. Each map is fully interactive — hover any molecule for detail and click it to jump straight to the matching Assay Genie antibody or ELISA kit. Colour-coded by protein class and built from validated targets, the collection spans checkpoint biology, co-stimulation, cell depletion, the tumour microenvironment, humoral immunity and the core signalling cascades — TCR, TLR, inflammasome, NK and JAK/STAT.
PD-1 / PD-L1 Immune Checkpoint
The inhibitory brake: PD-1 engaging PD-L1/PD-L2 recruits SHP-2 to shut down T-cell activation — and how blockade releases it.
T-Cell Co-Stimulation & Agonists
The accelerator: CD28-family and TNF-receptor co-stimulators that amplify T-cell responses, and the agonist antibodies that mimic them.
In Vivo Depletion Atlas
How depleting antibodies clear defined immune-cell subsets by ADCC, CDC and ADCP — with a click-through pick-list of targets.
Treg Suppression & IL-2 Axis
Regulatory T cells at work: the IL-2 sink, CTLA-4, IL-10/TGF-β, and JAK–STAT5→FOXP3 — plus the antibodies that deplete or disarm them.
Myeloid / TAM & MDSC Reprogramming
The tumour microenvironment: CSF-1R and GM-CSF driving suppressive TAMs and MDSCs, versus agonist anti-CD40 M1 repolarisation.
Cytokine Neutralisation Network
A map of the major cytokine axes — pro-inflammatory, Th2, immunosuppressive and T-cell-growth — and the In Vivo antibodies that block each.
B-Cell Activation & Germinal Centre
T-dependent humoral immunity: Tfh help, BCR signalling, class-switch and affinity maturation, and the plasma- and memory-cell fate switch.
TIGIT / DNAM-1 / CD155 Axis
The PVR-family balance: activating DNAM-1 versus inhibitory TIGIT, CD96 and PVRIG competing for the same CD155/CD112 ligands.
CD4 T-Helper Differentiation
How a naive CD4 T cell commits to Th1, Th2, Th17, iTreg or Tfh — each set by a polarising cytokine, a STAT and a master transcription factor.
T-Cell Receptor (TCR) Signalling
The full activation cascade: TCR/CD3 and CD28 through ZAP-70 and LAT into the NFAT, NF-κB, AP-1 and PI3K/AKT arms — with every checkpoint and phosphatase brake.
Toll-Like Receptor (TLR) & Innate Sensing
Surface and endosomal TLRs routing through MyD88 and TRIF to NF-κB and IRF3 — firing pro-inflammatory cytokines and type I interferon.
NLRP3 Inflammasome & Pyroptosis
The two-signal platform: priming and activation assembling NLRP3–ASC–caspase-1 to mature IL-1β/IL-18 and drive gasdermin-D pyroptosis.
NK Cell Activation & Cytotoxicity
The activating-versus-inhibitory balance — NKG2D, CD16 and DNAM-1 against KIR and NKG2A — deciding perforin/granzyme killing and IFN-γ release.
Cytokine JAK/STAT Signalling
Six receptor complexes end-to-end — JAK1/2/3 and TYK2 driving STAT1–6 to the nucleus — with the SOCS, SHP and PIAS brakes that tune every cytokine.