10731 results for 'RBP4/Retinol-Binding Protein 4'

Quick Facts About AnifrolumabWhat is Anifrolumab?Anifrolumab is a monoclonal antibody that targets the type I interferon receptor, playing a crucial role in treating systemic lupus eryt ...

PVR (Poliovirus receptor), also known as CD155, is a molecule that plays a dual role in regulating the immune response within the tumor microenvironment. While initially discovered as a ...

Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target f ...

What is the blood-brain barrier? The Blood-brain barrier (BBB) is a system of vessels that acts as a structural and chemical barrier between the brain and the rest of the body's circul ...

Understanding the Bcl-2 Pathway: Implications for Cancer Therapy The Bcl-2 family of proteins plays a pivotal role in regulating apoptosis, a crucial process for maintaining cellula ...

Quick Facts About PonsegromabWhat is Ponsegromab?Ponsegromab is an investigational monoclonal antibody developed by Pfizer, primarily studied for its potential in treating heart failure ...

Unregulated cell growthCancer, although heterogeneous by its very nature, can be broadly defined as a set of diseases characterised by unregulated cell growth leading to invasion of surroundin ...

Schwann cells are cells that play a vital role in nerve function. They are responsible for myelinating axons and helping to ensure the transmission of electrical signals between neurons. Schwann ...

Targeting USP22: A New Approach to Enhance Anticancer Immunity Introduction In the ever-evolving landscape of cancer research, the intricate relationship between immune ...

Explore the diverse roles and functionalities of granulocytes - neutrophils, eosinophils, basophils, and mast cells - as they form a critical line of defense in the immune system, res ...

Introduction to CD39 and Cancer Immunosuppression CD39 is an ectonucleotidase enzyme that plays a crucial role in generating adenosine, a powerful immunosuppressive molecule within ...

Rapid Antibody & Antigen tests available from Assay Genie ...

Introduction to KIR Blockade in Cancer ImmunotherapyNatural killer (NK) cells are crucial components of the innate immune system, responsible for recognizing and destroying virally infe ...

Hepatic Function Assays Liver function assays are a suite of tests designed to assess the health and efficacy of our vita ...

Quick Facts About VolagidemabWhat is Volagidemab?Volagidemab is a glucagon-like peptide-1 (GLP-1) receptor antagonist designed to regulate glucose metabolism and energy homeostasis.How ...

Fibroblasts, essential components of connective tissues, play vital roles in maintaining tissue structure and function. Their remarkable ability to produce and organize the extracellular matrix ...

Introduction to IL-10R and Immune Suppression in CancerThe interleukin-10 receptor (IL-10R) is a key player in regulating immune responses, particularly in suppressing inflammation and m ...

By Juan Quintana, PhD student, University of Edinbrugh What are Neglected Tropical Diseases (NTDs)? The World Health Orga ...

Sarah Brun Bar-Yaacov PhD Candidate, University of Liverpool Orthohantaviruses are a group of segmented negative-sense RNA viruses maintained as asympt ...

Imagine a microscopic sniper, capable of delivering a lethal blow to a single cancer cell while leaving its healthy neighbors virtually untouched. This is the promise of targeted alpha therapy, a re ...

Imagine a highly trained soldier, elite and effective, sent to the front lines of a relentless war. Day after day, they fight without rest, their supplies dwindle, and the enemy never stops coming. E ...

What Are Personalized Cancer Vaccines? Personalized cancer vaccines are a cutting-edge approach in cancer treatment that are designed to activate a patient's immune s ...

Recent advances in immunotherapy have highlighted the importance of targeting immune checkpoints to enhance the immune system’s ability to combat cancer. A new potential target in this g ...

Articular cartilage, a key player in joint function, owes its unique properties to its extracellular matrix (ECM). This complex, highly specialized structure is not only fundamental in maintainin ...

Immunophenotyping, a cornerstone of modern immunology, involves identifying and characterizing cell populations based on their surface markers. This technique provides insights into the hetero ...

Nuclear Factor Erythroid 2–Related Factor 2 (NRF2) orchestrates a principal defense mechanism against oxidative stress and plays a pivotal role in inflammation and disease pathogenesis. This arti ...

PD-L1 in Cancer Immunotherapy: Insights from Recent ResearchRecent advancements in cancer immunotherapy have underscored the critical role of programmed death-ligand 1 (PD-L1) in mediating immune eva ...

Quick Facts About PlonmarlimabWhat is Plonmarlimab?Plonmarlimab is a monoclonal antibody targeting GM-CSF, a cytokine involved in inflammation and immune responses.How does Plonmarlimab ...

Quick Facts About BasiliximabWhat is Basiliximab?Basiliximab is a monoclonal antibody targeting the CD25 subunit of the IL-2 receptor, primarily used to prevent organ transplant rejecti ...

What is Cystic Fibrosis? Cystic fibrosis (CF) is a genetic disorder that impairs the body's ability to produce sweat and thick mucus. CF causes mucus to build up in ...

The Ebola virus has been in the news a lot lately, but many people still don't know what it is or how it spreads. In this blog post, we will discuss the basics of the Ebola virus: w ...

The focus of this article is Tumor Suppressor Genes. There are various different types of tumor suppressor genes, with BRCA being one of the most popular. The role of Tumor Suppressor Genes in Ca ...

Antibiotic resistance is a growing problem in the world today. Antibiotics are becoming less and less effective as bacteria evolve to resist them. This poses a serious threat to hum ...

Stephen Reynolds, PhD Student, CERVIVA and Trinity College Dublin We hear almost daily now how everyone in their lifetime will be touched by cancer either directly or through a close f ...

What are Toll Like Receptors? Toll-like receptors (TLRs) are a class of proteins that play a crucial role in the immune system's defense against microbial invaders ...

Imagine a high-stakes game of hide-and-seek where the seeker is your immune system and the hider is a master of disguise: cancer. For decades, we believed the 'wanted' posters for tumor cells were l ...

Quick Facts About EldelumabWhat is Eldelumab?Eldelumab is a monoclonal antibody targeting TNFSF14 (LIGHT), a key regulator in immune system signaling, with potential applications in inf ...

Quick Facts About IanalumabWhat is Ianalumab?Ianalumab is a monoclonal antibody currently being investigated for its potential in treating autoimmune diseases, particularly lupus and im ...

Histamine, a biogenic amine, plays a crucial role in various physiological processes, including immune responses, gastric acid secretion, and neurotransmission. Central to the action of histamine ...

Monocytes, as part of the innate immune system, act as the first line of defense against foreign invaders. One of their primary functions is phagocytosis, a crucial process in which they engul ...

The myelin sheath is an insulating layer around nerve cells. It is made up of a substance called myelin, which is produced by special cells called oligodendrocytes. Myelin protects the nerve cell ...

Thanks to the great intuitions of brilliant scientists like Louis Pasteur, Edward Jenner, Robert Koch, Emil von Behring, Gaston Leon Ramon, Albert Sabin, Jonas Salk in the past century, the ...

Renal Cell Carcinoma (RCC) is the most common form of kidney cancer, originating in the lining of the proximal renal tubules. RCC accounts for approximately 90% of all kidney cancers and ...

Quick Facts About GlenzocimabWhat is Glenzocimab?Glenzocimab is an innovative monoclonal antibody designed to reduce the risk of ischemic stroke by selectively targeting platelet glycop ...

Shane O’Grady, PhD student, RCSI Cancer is a disease that will, unfortunately, touch all of our lives at some point, directly or indirectly. Despite decades ...

Transfection protocols play a crucial role in the realm of molecular biology and genetic research, enabling the introduction of foreign nucleic acids into living cells. This innovat ...

Understanding the immune system's intricacies requires models that accurately reflect its complexity. The rat, as a model organism, plays a crucial role in immunological research, particularly i ...

In this blog post, we will review prostate cancer markers and what you should look for in your results. Prostate antigen marker (PSA) and p63 are the most common markers found in pr ...

Understanding Lag-3, Tim-3, and TIGIT: Key Players in T Cell RegulationThe immune system's ability to regulate T cell responses is crucial for maintaining homeostasis and combating diseases such as c ...

Ovarian cancer is the fourth most common cancer in women. Ovarian cancer is when the normal cells in the ovary change and grow to form a tumour. Because the ovaries are located deep ...

Horseshoe crabs, often referred to as "living fossils," are invaluable to modern medicine due to their unique blue blood. This blood is the source of Limulus Amebocyte Lysate (LAL), a su ...

In the intricate landscape of the immune system, toll-like receptors (TLRs) play a fundamental role in the first line of defense against pathogens. These receptors, essential components of the in ...

Quick Facts About TinurilimabWhat is Tinurilimab?Tinurilimab is a monoclonal antibody targeting CD47, a protein that cancer cells use to evade immune system attack. By blocking CD47, Ti ...

T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to e ...

Cancer immunotherapy has revolutionized the treatment landscape for various malignancies. One of the most promising therapeutic strategies is the use of immune checkpoint inhibitors, par ...

Biomarkers, measurable indicators of biological processes or responses to therapeutic interventions, play a pivotal role in modern healthcare. They provide clinicians with valuable information ...

Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...

Introduction to FoxP3 and Regulatory T Cells in CancerFoxP3 (forkhead box P3) is a transcription factor critical for the development and function of regulatory T cells (Tregs), a special ...

In recent years, cancer immunotherapy has become a powerful tool for treating various malignancies. One promising approach involves targeting the tumor microenvironment, particularly reg ...

Hybridoma technology, a revolutionary method in immunology pioneered by Georges Köhler and César Milstein in the 1970s, has transformed the landscape of antibody production. This groundbreaking t ...

Quick Info Section: Key Facts About MogamulizumabWhat is Mogamulizumab?Mogamulizumab is an anti-CCR4 monoclonal antibody used primarily for treating certain cancers, including cutaneous ...

TIGIT (T cell immunoreceptor with Ig and ITIM domains) has emerged as a promising target in cancer immunotherapy and the treatment of autoimmune diseases. As a checkpoint receptor, TIGIT ...

by Ryan Wallis, PhD student, QMUL, Blizard Institute The microscopic world of cell biology was first explored by Robert Hooke in the 17th century and published in his work, Microgr ...

Radial glial cells are essential in shaping the nervous system, serving dual roles in neurogenesis and structural support during the brain's developmental stages. Key Takeaways: Rad ...

Mechanical forces are common in biological systems and dominate numerous perturbations that are relevant to human physiology and disease. Mechanobiology is a new field that evaluates the ef ...

Hypoxia-inducible factors (HIFs) are pivotal in the cellular response to oxygen deprivation. These transcription factors regulate various aspects of cellular and systemic homeostasis in response ...

By Charlotte O’Donnell PhD Inflammation and Cancer The link between inflammation and cancer is well established, with inf ...

Delving into the intricate world of Mitotic Catastrophe, this blog unveils its critical role in cell division and cancer therapy, offering insights into its mechanisms and potential treatments ...

Welcome to an exploration of the evolutionary trajectory and significance of the innate immune system - the body's first line of defense against invading pathogens. In this scientific jou ...

In the realm of biomedical imaging, the quest for precision and clarity drives researchers to explore innovative technologies. One such breakthrough is the Cy3 wavelength, a powerful tool revo ...

Alzheimer's disease stands as a formidable challenge in the realm of neurological disorders, characterized by its progressive nature and profound impact on cognitive functions. This article delv ...

Introduction to BTLA in Immune Regulation B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that plays a critical role in regulating immune responses by suppress ...

Extracellular Vesicles ...

In the intricate landscape of the brain, cells constantly communicate, sending and receiving messages that govern our thoughts, memories, and movements. For decades, scientists believed this communic ...

Interferons are key cytokines in the immune system, crucial for combating viral and bacterial infections, with significant roles in both innate and adaptive immunity responses. Key Takeaways ...

The CD28 molecule plays a crucial role in amplifying T cell activation, which is critical for mounting effective immune responses against tumors. By engaging with co-stimulatory molecule ...

Clinical pathology labs play a crucial role in modern healthcare, providing critical diagnostic testing services for a wide array of diseases and conditions. These laboratories are desig ...

What is Cell Synchronisation? Cell synchronisation is a process by which cells at different stages of the cell cycle in a culture are brought to the same phase. Cell synchronisation is ...

Introduction T lymphocytes are type of white blood cell that plays a crucial role in the immune system. There are many different types of T cells, and it is important to be able to di ...

In the realm of biological and biochemical research, solutions play a pivotal role in various experimental procedures, from cell culture to molecular biology assays. Among the plethora of solu ...

Introduction to TLR4 and Cancer Toll-like receptor 4 (TLR4) is a key component of the innate immune system, primarily responsible for detecting infections and initiating inflammator ...

In the realm of biological and biochemical research, solutions play a pivotal role in various experimental procedures, from cell culture to molecular biology assays. Among the plethora ...

Hypoxia, or low oxygen levels, poses a significant challenge to cells, necessitating rapid and efficient adaptation mechanisms. The Hypoxia-Inducible Factor (HIF) pathway is a well-known regul ...

CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Help ...

Treponema pallidum, the causative agent of syphilis, triggers an immune response that produces antibodies detectable by laboratory tests. Diagnosing syphilis often involves detecting the ...

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PharmaGenie ELISA Validated According to ISO Quality Systems Highly validated ELISA designed to exceed the needs of biopharma R&D s ...

We started Assay Genie from a small facility in 2017 to solve the biggest problems facing R&D scientists: how to achieve optimal resu ...

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What is IHC? Immunohistochemistry (IHC) is a valuable tool used for the identification of specific antigens within embedded tissue prepara ...

Brochures & FlyersFind the information you needExplore Assay Genie's collection of scientific brochures and product flyers featuring our ELISA kits, antibodies, proteins, and custom ...

Autophagy Cardiovascular Cell Biology Cell Cycle Cell Death COVID-19 Developmental Biology Epigenetics & Nuclear Signaling Flow Cytometry Immunology Loading Con ...

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Phosphorylation ELISA Screen cell lysates without Western Blot analysis! Determine phosphorylated protein to verify pathway activation! ...

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Antibody Arrays Detect 7-274 proteins in 10 species! Perfect for biomarker discovery and validation studies! Browse by Research Area ...

Epigenetic Antibodies Epigenteic Antibodies Organised by Epigenetic Modifications! window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Arr ...

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What is DNA Polymerase Fidelity? The fidelity of a DNA polymerase is the result of accurate replication of a desired template. The fidelity of DNA polymerase ...