Blog
The Role of Tumor Suppressor Genes in Cancer: Knudson Hypothesis & Oncogenes
The focus of this article is Tumor Suppressor Genes. There are various different types of tumor suppressor genes, with BRCA being one of the most popular. The role of Tumor Suppresso
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25th Aug 2023
Biomarkers & Inflammatory markers of atherosclerosis
As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progr
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25th Aug 2023
Antibody Conjugation: Techniques and Applications
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window.SHOGUN_IMAGE_V2_ELEMENTS.push({ uuid: 's-d889a991-c5d1-437c-b4cb-b24257d04234' })
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24th Aug 2023
Myeloid Lineage: Pioneers of Immune Cell Production
Myeloid lineage plays a crucial role in the immune system and hematopoiesis, encompassing various c
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25th Jul 2023
Fibroblast Markers
Fibroblasts, essential components of connective tissues, play vital roles in maintaining tissue str
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20th Jul 2023
von Willebrand Factor and Cancer
What is von Willebrand Factor?
Von Willebrand Factor (VWF) is a crucial glycoprotein that plays
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18th Jul 2023
Cancer Metabolism: Tumorigenesis, Metabolic Therapy & The Warburg Effect
Cancer Metabolism is the mechanism by which cancer cells make energy in order for them to grow and spread. Even in the presence of oxygen, cancer cells increase glucose uptake and pr
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14th Jul 2023
What is RNAi? All You Need to Know
RNA interference (RNAi), also referred to as Post-Transcriptional Gene Silencing (PTGS), is the process by which RNA molecules silence genes in response to double-stranded RNA. R
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13th Jul 2023
Mitotic Catastrophe Review
This blog focusses on the underlying mechanisms and consequences of this intriguing phenomenon, whi
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11th Jul 2023
Cyclins and Cyclin Dependent Kinase – Review
Introduction
Cyclins, a family of proteins, play a crucial role in regulating the cell cycle by acting as essential acti
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10th Jul 2023
The p53 Protein: Tumor Suppressor Protein
What is p53?
p53 is a crucial protein involved in the regulation of cell division and serves as a key protector against the formation of cancerous t
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5th Jul 2023
Dendritic Cells - Markers, Activation & Subtypes
What is a Dendritic Cell?
Dendritic cells (DCs) are a type of immune cell that acts as a messenger between the innate and adaptive immune system. They are pro
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12th Jun 2023
TNF alpha & Inflammation
What is TNF alpha?
Tumour necrosis factor alpha (TNF alpha) is a transmembrane protein (molecular weight of TNF alpha - 26 kDa) and a member of the TNF superfa
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8th Jun 2023
The Role of Claudins in Cancer
Introduction
Claudins are a family of proteins that play a critical role in the formation of t
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16th Mar 2023
Ovarian Cancer: Symptoms, Causes, Diagnosis and Treatment
Ovarian cancer is the fourth most common cancer in women. Ovarian cancer is when the normal cells in the ovary change and grow to form a tumour. Because the ovaries are located deep
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3rd Apr 2022
Chronic myelogenous leukaemia (CML) – Review
Chronic myelogenous leukaemia (CML) is a myeloproliferative haematopoietic malignancy, characterised by a karyotypic abnormality present in more than 95% of cases known as the Philadelph
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1st Apr 2022
Leukemia Inhibitory Factor: An Overview
Leukemia Inhibitory Factor and JAK-STAT Signalling Pathway
Leukemia inhibitory factor (LIF) is a cytokine that belongs to the interleukin-6 (IL-6) family of cytokines. Other members of
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24th Mar 2022
Esophageal Cancer: Causes, Symptoms, Diagnosis, Treatment, and Prevention
Esophageal cancer is a type of cancer that affects the esophagus, which is the tube that carries food and liquids from your mouth to your stomach. Esophageal cancer can cause many di
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21st Mar 2022
Prostate Cancer Markers : What to Look for in Your Test Results
In this blog post, we will review prostate cancer markers and what you should look for in your results. Prostate antigen marker (PSA) and p63 are the most common markers found in pro
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21st Mar 2022
Cancer Research Club - RCSI
Our Cancer Research Club symposium series continued on Wednesday afternoon, at Royal College of Surgeons (RCSI), Dublin, Ireland. The Bouchier-Hayes lecture theatre was at maximum capa
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6th Oct 2021
HERV-K group of endogenous retroviruses and cancer
In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germl
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6th Oct 2021
Acute Lymphoblastic Leukaemia Review | Assay Genie
Incidence rate of Acute Lymphoblastic Leukaemia
Acute lymphoblastic leukaemia (ALL) is one of the most common malignant diseases diagnosed in children. It
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20th Aug 2021
The common characteristics of cancer | Assay Genie
By Shane Houston, PhD Candidate Queen’s University Belfast
Cancer is an age old adversary of the human race. This out-of-control growth of abnormal cells has been a shadow over human health t
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20th Aug 2021
Microcalcifications in breast cancer: Novel insights into the molecular mechanism and functional consequences
Shane O’Grady, PhD student, RCSI
Cancer is a disease that will, unfortunately, touch all of our lives at some point, directly or indirectly. Despite decades
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15th Mar 2021