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Cell Cycle · KinasesCyclins and Cyclin-Dependent Kinases: Regulation, Substrates and Mitotic ControlCDKs are inactive on their own. They require a cyclin partner, and because cyclin levels rise and fall on a schedule, the cell cycle advances in a fixed order. This guide covers which cyclin pairs with which CDK, how the CDK1-cyclin B complex drives mitotic entry through positive feedback, the substrate motif that made proteomic mapping possible, the Cdk1-Plk1-Aurora B hierarchy, and how cyclin destruction ends mitosis.Browse cell cycle antibodies →1982Hunt discovers cyclins in sea urchinsCDK1–CDK20The renamed kinase familyS/T-P-X-K/RThe CDK1 substrate motifAPC/C–Cdc20Destroys cyclin B at anap …

What is Hepatocyte Growth Factor? Hepatocyte growth factor (HGF) is a cytokine that is mainly produced by the liver. HGF is a pleiotrophic cytokine that regulates cell growth, motility, and morphogenesis. The majority of HGF is produced by the liver, but it is also expressed in other organs, such as the kidney, pancreas, and intestine. HGF binds to its cognate receptor, c-Met, which is present on the surface of many types of cells. However, it has no measurable protease activity. Binding of HGF to c-Met leads to activation of multiple signaling pathways that promote cell proliferation, survival, migration, and differentiation. Key Takeaways Hepatocyte Growth Factor …