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Blog

Reprogramming Regulatory T Cells: A Breakthrough in Cancer Immunotherapy

A New Dawn in Cancer Treatment: Reprogramming the Immune System's Own Soldiers For decades, the fight against cancer has been a relentless battle of attrition, with treatments like chemotherapy and radiation often causing significant collateral damage to the patient's body. However, a new era of cancer therapy is dawning, one that harnesses the power of our own immune system to fight back. This field, known as cancer immunotherapy, has seen remarkable progress, and a recent breakthrough from scientists at Indiana University School of Medicine is poised to revolutionize how we approach some of the most aggressive forms of the disease. The Double-Edged Sword: Regulatory T Cells Our immune s …
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19th Nov 2025 Seán Mac Fhearraigh, PhD

CTLA-4 in Breast Cancer: Insights for Immunotherapy

The Role of CTLA-4 in Breast Cancer: Implications for ImmunotherapyBreast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, with significant morbidity and mortality rates. As the understanding of cancer biology evolves, the role of the immune system in tumor progression and response to therapy has gained prominence. Recent research has identified CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) as a significant player in the immune response to breast cancer. This article explores the expression of CTLA-4 in breast cancer, highlighting its potential as a clinical marker and a target for immunotherapy, which could enhance treatment strategies for patients.Introduct …
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1st Aug 2025 Seán Mac Fhearraigh, PhD
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