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Understanding Zonulin: Key Regulator of Intestinal Barrier Function Zonulin is a crucial physiological modulator of intercellular tight junctions, playing a significant role in regulating intestinal permeability. This article explores the implications of zonulin in various autoimmune diseases, including celiac disease and type 1 diabetes, and highlights the importance of understanding its biological mechanisms. Introduction Zonulin is the only known physiological modulator of intercellular tight junctions, which are essential for maintaining the integrity of the intestinal barrier. Disruption of this barrier can lead to increased intestinal permeability, often referred to as "leaky gut," …