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By Sinead Kinsella PhD The Ubiquitin Proteasome System (UPS) The Ubiquitin Proteasome System (UPS) is a regulatory machinery for protein turnover in the cell (Pickart, 2001), and strict regulation of the balance between protein synthesis and degradation is essential for cellular homeostasis (Gaczynska et al., 2001). The UPS is composed of the ubiquitination system, which governs the labelling of proteins for degradation, and the proteasome, which carries out protein degradation (Jansen et al., 2014). Ubiquitin degradation is a highly regulated process with specific targeting of the protein with ubiquitin molecules prior to degradation by the …