UniProt Protein Function: | Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q9QZL0 |
NCBI GenInfo Identifier: | 256017133 |
NCBI Gene ID: | 56532 |
NCBI Accession: | NP_064339.2 |
UniProt Secondary Accession: | Q9QZL0,Q3U3Z9, Q8K2Y2, G3X8V8 |
UniProt Related Accession: | Q9QZL0 |
Molecular Weight: | 46-62 |
NCBI Full Name: | receptor-interacting serine/threonine-protein kinase 3 isoform 1 |
NCBI Synonym Full Names: | receptor-interacting serine-threonine kinase 3 |
NCBI Official Symbol: | Ripk3Â Â |
NCBI Official Synonym Symbols: | Rip3; AW107945; 2610528K09Rik  |
NCBI Protein Information: | receptor-interacting serine/threonine-protein kinase 3 |
UniProt Protein Name: | Receptor-interacting serine/threonine-protein kinase 3 |
UniProt Synonym Protein Names: | RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; mRIP3 |
Protein Family: | Putative zinc metalloprotease |
UniProt Gene Name: | Ripk3Â Â |
UniProt Entry Name: | |