Blog
Ubiquitin and Its Role in Cellular Regulation: A Comprehensive Overview of Modifiers and Pathways
Ubiquitin is a small, highly conserved protein found in eukaryotic cells that plays a crucial role in regulating various cellular processes. The process of ubiquitination involves the covalent att
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23rd Jan 2024
Hybridoma Technology: Revolutionizing Antibody Production
Hybridoma technology, a revolutionary method in immunology pioneered by Georges Köhler and César Milstein in the 1970s, has transformed the landscape of antibody production. This groun
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23rd Jan 2024
Mesenchymal Stem Cells: Navigating the Frontiers of Regenerative Medicine
Mesenchymal stem cells (MSCs) have emerged as pivotal players in the realm of regenerative medicine due to their unique properties and versatile potential. Originally discovered in the bone marrow
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23rd Jan 2024
MAPK Signaling in Inflammatory Cytokines Pathways
The Mitogen-Activated Protein Kinase (MAPK) pathway is a pivotal signaling cascade that plays a crucial role in mediating cellular responses to various external stimuli. This pathway is intricatel
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22nd Jan 2024
VEGF-A VEGFR-2 Signaling: Decoding the Blueprint of Angiogenesis for Therapeutic Insights
The orchestration of angiogenesis, the process by which new blood vessels form from pre-existing ones, is a complex symphony regulated by various molecular players. At the forefront of this int
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18th Jan 2024
Dendritic Cells: Tracing the Developmental Lineage Pathway
Dendritic cells (DCs) are pivotal in the immune system, orchestrating innate and adaptive immune responses. Understanding their developmental lineage pathway is crucial in immunology, particularly
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5th Jan 2024
Understanding CD16: A Comprehensive Overview
CD16, also known as FcγRIII (Fc gamma receptor III), plays a crucial role in the immune system, serving as a receptor for the Fc region of immunoglobulin G (IgG). This receptor is a key play
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5th Jan 2024
Understanding the mTOR Signaling Pathway: A Key Player in Cell Growth and Metabolism
The mammalian target of rapamycin (mTOR) signaling pathway is a crucial regulator of cell growth and metabolism, responding to environmental cues and cellular energy status. This pathway's signifi
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5th Jan 2024
Understanding CD16: A Comprehensive Overview
CD16, also known as FcγRIII (Fc gamma receptor III), plays a crucial role in the immune system, serving as a receptor for the Fc region of immunoglobulin G (IgG). This receptor is a key play
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5th Jan 2024
Deciphering the Intricacies of TGF-Beta Signaling Pathway
Transforming Growth Factor-Beta (TGF-β) signaling pathway plays a pivotal role in orchestrating various cellular processes, ranging from embryonic development to tissue homeostasis and immune
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24th Aug 2023
The role of IFN gamma in inflammation, cancer and autoimmune disease
Interferons are key cytokines in the immune system, crucial for combating viral and bacterial infections, with significant roles in both innate and adaptive immunity responses. Key Takeaways
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22nd Aug 2023
The Lenti Viral Vector System: A New Way to Deliver Genetic Therapies
A new way to deliver genetic therapies is making waves in the medical world. The lenti virus vector system has been shown to be more effective than traditional methods of gene therap
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18th Aug 2023
What is RNAi? All You Need to Know
RNA interference (RNAi), also referred to as Post-Transcriptional Gene Silencing (PTGS), is the process by which RNA molecules silence genes in response to double-stranded RNA. RNA interference (R
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13th Jul 2023
Immunometabolism – A therapeutic perspective
What is Immunometabolism?
Immunometabolism is an exponentially growing, multi-disci
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10th Jul 2023
How do different types of vaccines work?
What is a vaccine?
A vaccine is a pharmacological product that gives the recieving patient's immune system a chance to learn how to fight infection with decreased risk of illness. Vacci
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21st Apr 2022
What is pharmacogenomics?
What is pharmacogenomics
Pharmacogenomics is how DNA variation and drugs interact and how this can optimise patient health; this involves studying pharmacokinetics and pharmacodynamics.
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10th Apr 2022
Novel Gene Therapy for Cystic Fibrosis
Novel Gene Therapies for Cystic Fibrosis
Cystic Fibrosis
Cystic fibrosis (CF) is an autosomal recessive, life-limiting disease resulting from gene mutations that encode the cystic fibr
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6th Apr 2022
Pyroptosis: A Promising Target for Immunotherapy
Pyroptosis is an immunogenic form of cell death, meaning that it triggers an immune response. This makes pyroptosis a potentially promising target for immunotherapies that aim to boo
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22nd Mar 2022
PD-1 & PD-L1 Inhibitors
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21st Jan 2022
Anti-CTLA-4 Immunotherapy
CD Markers
Cluster of Differentiation (CD) markers play an important role in the differentiation of B cells, T cells and NK (natural killer) ce
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11th Jan 2022
Galectin Therapeutics
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, irreversible and ultimately fatal disease characterized by prog
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27th Sep 2021
TLX as a Novel Therapeutic Target
Danka Kozareva PhD Candidate, University College Cork
The generation of neurons from stem cells
The process of generating
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1st Jan 1970