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Anti-FMO2 Antibody (CAB13981)

SKU:
CAB13981
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€129 - €359
Frequently bought together:

Description

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Antibody Name:Anti-FMO2 Antibody
Antibody SKU:CAB13981
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-470 of human FMO2 (NP_001451.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-470 of human FMO2 (NP_001451.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VFIS TRHG TWVM SRIS EDGY PWDS VFHT RFRS MLRN VLPR TAVK WMIE QQMN RWFN HENY GLEP QNKY IMKE PVLN DDVP SRLL CGAI KVKS TVKE LTET SAIF EDGT VEEN IDVI IFAT GYSF SFPF LEDS LVKV ENNM VSLY KYIF PAHL DKST LACI GLIQ PLGS IFPT AELQ ARWV TRVF KGLC SLPS ERTM MMDI IKRN EKRI DLFG ESQS QTLQ TNYV DYLD ELAL EIGA KPDF CSLL FKDP KLAV RLYF GPCN S
Gene ID:2327
Uniprot:Q99518
Cellular Location:Endoplasmic reticulum membrane, Microsome membrane
Calculated MW:53kDa
Observed MW:Refer to figures
Synonyms:FMO2, FMO1B1
Background:This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FMO2: Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. Belongs to the FMO family.
UniProt Protein Details:

Protein type:EC 1.14.13.8; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q24.3

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function:FAD binding; NADP binding; monooxygenase activity; flavin-containing monooxygenase activity

Biological Process: organic acid metabolic process; toxin metabolic process; xenobiotic metabolic process; drug metabolic process; NADP metabolic process

NCBI Summary:This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
UniProt Code:Q99518
NCBI GenInfo Identifier:327478599
NCBI Gene ID:2327
NCBI Accession:Q99518.4
UniProt Secondary Accession:Q99518,Q5EBX4, Q86U73, Q9BRX1,
UniProt Related Accession:Q99518
Molecular Weight:471
NCBI Full Name:Dimethylaniline monooxygenase
NCBI Synonym Full Names:flavin containing monooxygenase 2 (non-functional)
NCBI Official Symbol:FMO2  
NCBI Official Synonym Symbols:FMO1B1  
NCBI Protein Information:dimethylaniline monooxygenase [N-oxide-forming] 2; dimethylaniline monooxygenase [N-oxide-forming] 2; FMO, pulmonary; dimethylaniline oxidase 2; pulmonary flavin-containing monooxygenase 2
UniProt Protein Name:Dimethylaniline monooxygenase [N-oxide-forming] 2
UniProt Synonym Protein Names:Dimethylaniline oxidase 2; FMO 1B1; Pulmonary flavin-containing monooxygenase 2; FMO 2
Protein Family:Dimethylaniline monooxygenase
UniProt Gene Name:FMO2  
UniProt Entry Name:FMO2_HUMAN

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