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Anti-FSHB Antibody (CAB5313)

SKU:
CAB5313
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€129 - €359
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Description

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Antibody Name:Anti-FSHB Antibody
Antibody SKU:CAB5313
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-129 of human FSHB (NP_000501.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-129 of human FSHB (NP_000501.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NSCE LTNI TIAI EKEE CRFC ISIN TTWC AGYC YTRD LVYK DPAR PKIQ KTCT FKEL VYET VRVP GCAH HADS LYTY PVAT QCHC GKCD SDST DCTV RGLG PSYC SFGE MKE
Gene ID:2488
Uniprot:P01225
Cellular Location:Secreted
Calculated MW:14kDa
Observed MW:16kDa
Synonyms:FSHB, HH24
Background:The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.
UniProt Protein Function:FSHB: Stimulates development of follicle and spermatogenesis in the reproductive organs. Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Belongs to the glycoprotein hormones subunit beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm; extracellular region

Molecular Function:follicle-stimulating hormone activity; hormone activity; protein binding

Biological Process: female gamete generation; female pregnancy; peptide hormone processing; progesterone biosynthetic process; signal transduction; transforming growth factor beta receptor signaling pathway

Disease: Follicle-stimulating Hormone Deficiency, Isolated

NCBI Summary:The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:P01225
NCBI GenInfo Identifier:120552
NCBI Gene ID:2488
NCBI Accession:P01225.2
UniProt Secondary Accession:P01225,Q14D61, A2TF08, A5JVV3,
UniProt Related Accession:P01225
Molecular Weight:14,700 Da
NCBI Full Name:Follitropin subunit beta
NCBI Synonym Full Names:follicle stimulating hormone beta subunit
NCBI Official Symbol:FSHB  
NCBI Official Synonym Symbols:HH24  
NCBI Protein Information:follitropin subunit beta
UniProt Protein Name:Follitropin subunit beta
UniProt Synonym Protein Names:Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain
Protein Family:Follitropin
UniProt Gene Name:FSHB  
UniProt Entry Name:FSHB_HUMAN

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