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Anti-Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 Antibody (CABP0280)

SKU:
CABP0280
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€329 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 Antibody
Antibody SKU:CABP0280
Antibody Size:50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S246 of human HDAC4
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100
Reactivity:Human
Positive Samples:293, 293+EGF
Immunogen:A phospho specific peptide corresponding to residues surrounding S246 of human HDAC4
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9759/10014/9734
Uniprot:P56524/Q9UQL6/Q9UKV0
Cellular Location:
Calculated MW:57-65kDa/97-122kDa
Observed MW:125kDa/140kDa
Anti-Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 Antibody (CABP0280)Western blot analysis of extracts from 293 cells untreated or treated with EGF using Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 Antibody (CABP0280). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA.
Synonyms:HDAC4/HDAC5/HDAC9
Background:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

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