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Anti-PRKAG2 Antibody (CAB14480)

SKU:
CAB14480
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
€129 - €359
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Description

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Antibody Name:Anti-PRKAG2 Antibody
Antibody SKU:CAB14480
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human PRKAG2 (NP_077747.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human PRKAG2 (NP_077747.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLEK LEFE DEAV EDSE SGVY MRFM RSHK CYDI VPTS SKLV VFDT TLQV KKAF FALV ANGV RAAP LWES KKQS FVGM LTIT DFIN ILHR YYKS PMVQ IYEL EEHK IETW RELY LQET FKPL VNIS PDAS LFDA VYSL IKNK IHRL PVID PISG NALY ILTH KRIL KFLQ LFMS DMPK PAFM KQNL DELG IGTY HNIA FIHP DTPI IKAL NIFV ERRI SALP VVDE SGKV VDIY SKFD VINL AAEK TYNN LDIT VTQA LQHR SQYF EGVV KCNK LEIL ETIV DRIV RAEV HRLV VVNE ADSI VGII SLSD ILQA LILT PAGA KQKE TETE
Gene ID:51422
Uniprot:Q9UGJ0
Cellular Location:
Calculated MW:37kDa/58kDa/63kDa
Observed MW:Refer to Figures
Synonyms:PRKAG2, AAKG, AAKG2, CMH6, H91620p, WPWS
Background:AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniProt Protein Function:AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
NCBI Summary:AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]
UniProt Code:Q9UGJ0
NCBI GenInfo Identifier:100913192
NCBI Gene ID:51422
NCBI Accession:NP_001035723.1
UniProt Secondary Accession:Q9UGJ0,Q53Y07, Q6NUI0, Q75MP4, Q9NUZ9, Q9UDN8, Q9ULX8
UniProt Related Accession:Q9UGJ0
Molecular Weight:Observed: 65 kDaPredicted: 64 kDa
NCBI Full Name:5'-AMP-activated protein kinase subunit gamma-2 isoform c
NCBI Synonym Full Names:protein kinase AMP-activated non-catalytic subunit gamma 2
NCBI Official Symbol:PRKAG2  
NCBI Official Synonym Symbols:AAKG; CMH6; WPWS; AAKG2; H91620p  
NCBI Protein Information:5'-AMP-activated protein kinase subunit gamma-2
UniProt Protein Name:5'-AMP-activated protein kinase subunit gamma-2
UniProt Synonym Protein Names:H91620p
Protein Family:5'-AMP-activated protein kinase
UniProt Gene Name:PRKAG2  

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