null

Anti-S100A1 Antibody (CAB8560)

SKU:
CAB8560
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
€129 - €359
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-S100A1 Antibody
Antibody SKU:CAB8560
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human S100A1 (NP_006262.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human S100A1 (NP_006262.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGSE LETA METL INVF HAHS GKEG DKYK LSKK ELKE LLQT ELSG FLDA QKDV DAVD KVMK ELDE NGDG EVDF QEYV VLVA ALTV ACNN FFWE NS
Gene ID:6271
Uniprot:P23297
Cellular Location:Cytoplasm
Calculated MW:10kDa
Observed MW:Refer to figures
Synonyms:S100, S100-alpha, S100A, S100A1
Background:The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
UniProt Protein Function:Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. Ref.13
UniProt Protein Details:

Subunit structure: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Ref.8 Ref.9 Ref.10 Ref.11 Ref.13 Ref.14

Subcellular location: Cytoplasm.

Tissue specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.

Sequence similarities: Belongs to the S-100 family.Contains 2 EF-hand domains.

NCBI Summary:The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
UniProt Code:P23297
NCBI GenInfo Identifier:134136
NCBI Gene ID:6271
NCBI Accession:P23297.2
UniProt Secondary Accession:P23297,Q5T7Y3, B2R5D9,
UniProt Related Accession:P23297
Molecular Weight:
NCBI Full Name:Protein S100-A1
NCBI Synonym Full Names:S100 calcium binding protein A1
NCBI Official Symbol:S100A1  
NCBI Official Synonym Symbols:S100; S100A; S100-alpha  
NCBI Protein Information:protein S100-A1; S100 alpha; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1; S100 protein, alpha polypeptide
UniProt Protein Name:Protein S100-A1
UniProt Synonym Protein Names:S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1
UniProt Gene Name:S100A1  
UniProt Entry Name:S10A1_HUMAN

Related Products