10479 results for 'signal transduction'

Fluorescent proteins (FPs) have revolutionized the field of molecular and cellular biology, allowing scientists to visualize and track biological processes in live cells with unprecedented clarit ...

Enzyme-Linked Immunosorbent Assay (ELISA) is a powerful analytical biochemistry assay that utilizes antibodies and color change to identify a substance. It is widely used in the field of immunolo ...

Quick Facts About SirexatamabWhat is Sirexatamab?Sirexatamab is an investigational monoclonal antibody designed to target CD47, a key immune checkpoint involved in cancer evasion.How Do ...

Quick Facts About RuplizumabWhat is Ruplizumab?Ruplizumab is an investigational monoclonal antibody designed to target CD47, a protein that helps cancer cells evade immune detection.Wha ...

We know it gets tiring being in the lab every day, especially with the evenings getting darker and gloomier. So, to get you in the festive spirit, we're holding a competition to win money to t ...

Adhesion Molecules Direct cell-cell interactions are maintained and regulated by cell adhesion molecules. The expression of adhesion molecule ...

Quick Facts About RagifilimabWhat is Ragifilimab?Ragifilimab is an investigational anti-CD47 monoclonal antibody developed to block the CD47-SIRPα interaction, thereby enhancing macroph ...

For decades, the fight against cancer has been a story of incremental gains. But what if we could fundamentally shift the battlefield, turning the body's own immune system into a precision-guided wea ...

In the dynamic landscape of biomedical research, organoids have emerged as a groundbreaking tool, offering three-dimensional (3D) models that mimic the complex architecture and functionality of h ...

What are Toll Like Receptors? Toll-like receptors (TLRs) are a class of proteins that play a crucial role in the immune system's defense against microbial invaders ...

Quick Info Section: Key Facts About CevostamabWhat is Cevostamab?Cevostamab is an investigational monoclonal antibody targeting CD47, a cell surface protein that helps cancer cells evad ...

Cancer DevelopmentCancer is a group of diseases that involves abnormal cell growth resulting in malignant tumours/ malignant neoplasms. Cancer is a leading cause of morbidity, with 14 million n ...

Microglia Astrocytes Oligodendrocytes Glial ...

What is CD31? CD31, also known as PECAM-1, was originally described as a cell surface antigen present on platelets and megakaryocytes. CD31 is ...

Tumor-Associated Macrophages: Double Agents in the Cancer Battlefield In the intricate theater of the human body, the immune system acts as a vigilant guardian, dispatching cellular soldiers to seek ...

Quick Facts About GalegenimabWhat is Galegenimab?Galegenimab is an anti-CD47 monoclonal antibody designed to block the "don't eat me" signal, enhancing the immune system's ability to el ...

CAR T-cell therapy CAR (Chimeric Antigen Receptor) T-cell Therapy is a type of cancer treatment. CAR T-cells are made in the laboratory and they have an artificially created receptor on th ...

Background I am a 3rd year PhD student in Trinity College Dublin and my project is very much an interdisciplinary one. I’m very lucky to get to work between two great labs, Dr. Aisling Dun ...

Written by Seán Mac Fhearraigh, PhD  •  Updated: 19 May 2026  •  ~10 min read Quick Answer A sandwich ELISA uses two antib ...

Quick Facts About TidutamabWhat is Tidutamab?Tidutamab is a monoclonal antibody designed to target somatostatin receptor 2 (SSTR2), a key protein involved in various neuroendocrine tumo ...

Quick Facts About NarnatumabWhat is Narnatumab?Narnatumab is a monoclonal antibody targeting CD47, a key immune checkpoint that helps cancer cells evade destruction by the immune system ...

Quick Facts About TinurilimabWhat is Tinurilimab?Tinurilimab is a monoclonal antibody targeting CD47, a protein that cancer cells use to evade immune system attack. By blocking CD47, Ti ...

Quick Facts About EnavatuzumabWhat is Enavatuzumab?Enavatuzumab is a monoclonal antibody targeting the TWEAK receptor (Fn14), pivotal in tumor growth and immune regulation.What is the m ...

Platelets, the tiny cellular fragments found in our blood, play a crucial role in maintaining our overall health and well-being. From their role in blood clotting to their involveme ...

The Brain's Sentinels: How Microglia Shape Neuroinflammation in Disease In the intricate landscape of the human brain, a silent, ever-watchful guardian stands ready to defend against injury and inva ...

The focus of this article is Tumor Suppressor Genes. There are various different types of tumor suppressor genes, with BRCA being one of the most popular. The role of Tumor Suppressor Genes in Ca ...

Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...

Introduction to PD-1, PD-L1, and PD-L2 in Cancer ImmunotherapyThe PD-1/PD-L1 immune checkpoint pathway has been instrumental in cancer immunotherapy, with PD-1 (programmed death-1) inhib ...

Thanks to the great intuitions of brilliant scientists like Louis Pasteur, Edward Jenner, Robert Koch, Emil von Behring, Gaston Leon Ramon, Albert Sabin, Jonas Salk in the past century, the ...

Vascular Endothelial Growth Factor A (VEGFA) is a pivotal signaling protein involved in both vasculogenesis and angiogenesis, processes essential for the formation of blood vessels during embryon ...

Quick Facts About FletikumabWhat is Fletikumab?Fletikumab is an investigational monoclonal antibody targeting CD47, a key immune checkpoint that enables cancer cells to evade immune des ...

What You Need to Know About DupilumabWhat is Dupilumab?Dupilumab is a fully human monoclonal antibody designed to treat various chronic inflammatory diseases by inhibiting key cytokines ...

HMGB1 Functional Overview High mobility group box 1 ( HMGB1), a member of the high-mobility group (HMG) family, was first identified in the thymus in 1973 a ...

Quick Facts About EldelumabWhat is Eldelumab?Eldelumab is a monoclonal antibody targeting TNFSF14 (LIGHT), a key regulator in immune system signaling, with potential applications in inf ...

Quick Facts About FezakinumabWhat is Fezakinumab?Fezakinumab is a human IgG1-lambda monoclonal antibody that targets interleukin-22 (IL-22), a cytokine involved in inflammatory response ...

Harnessing the immune system to fight cancer has become a pivotal strategy in modern oncology. A key component in this fight is CD27, a receptor that plays a crucial role in T-cell activ ...

The immune system is the body’s main defence against infection. In order to function properly, the immune system must be able to detect and protect against infinite agents s ...

Spindle assembly checkpoint The spindle assembly checkpoint (SAC), or mitotic checkpoint, is the main cell cycle control mechanism that governs mitosis. Incorre ...

This article provides an overview of the protein Zonulin (function, structure, location). It describes tight junction proteins, leaky gut and Zonulin-related diseases. This includes celiac diseas ...

Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early unders ...

Quick Facts About RamucirumabWhat is Ramucirumab?Ramucirumab is a monoclonal antibody that targets vascular endothelial growth factor receptor 2 (VEGFR-2), inhibiting angiogenesis, a pr ...

David Melamed, Phd Candidate, Colombia University When I started in the Kalderon Lab five years ago, I had no idea that our work would lead us to drastica ...

In the complex world of biochemical processes, enzymes play a crucial role in catalyzing various reactions necessary for life. Among these enzymes, proteases and peptidases are fundamental pla ...

Overview of Diabetes Mellitus Diabetes mellitus (DM) is a major epidemic that affects over 347 million people worldwide (Danaei et al. 2011). The World He ...

The Double-Edged Sword: How Neutrophil Traps Can Both Help and Hinder Cancer's Spread In the intricate battlefield of the human body, the immune system’s foot soldiers, neutrophils, have long been r ...

Immunotherapy has become a central pillar in the fight against cancer, with a focus on enhancing the body’s natural defenses. Among the molecules at the forefront of immunotherapeutic re ...

Flow Cytometry Protocol The meaning is in the name: Flow = in motion, Cyto = cells, Metry = measure. What is Flow Cytometry? Flow c ...

What You Need to Know About CodrituzumabWhat is Codrituzumab?Codrituzumab is an investigational monoclonal antibody targeting CD47, an immune checkpoint that regulates immune responses ...

Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Pancreatic can ...

Key Facts About EtigilimabWhat is Etigilimab?Etigilimab is an anti-TIGIT monoclonal antibody being studied for its potential role in cancer immunotherapy.What role does Etigilimab play ...

T cells are central players in adaptive immunity, responsible for recognizing and eliminating infected or aberrant cells. Upon encountering antigens, T cells undergo clonal expansion and diffe ...

Nanosilver is the most commercialised nanoparticle routinely used for its antibacterial purposes in food preservation, cosmetic and health products such as medical devices and wound treatme ...

Quick Facts About RosopatamabWhat is Rosopatamab?Rosopatamab is a monoclonal antibody targeting CD47, a critical immune checkpoint that helps cancer cells evade immune detection. By blo ...

Traumatic injuries & death When I ask people what the leading cause of death is in the United States in people age 44 and under, they generally reply saying ...

Key Takeaways: Microglia are immune cells in the CNS, originating from myeloid precursor cells. They surveil the CNS, respond to changes, and maintain neural health. Microglia exist in dif ...

The fight against B cell cancers, a challenging spectrum of hematologic malignancies, has entered a new era with the introduction of rituximab biosimilars. These biosimilars promise to extend th ...

Dr. Melissa Conroy, TTMI I am an immunologist and senior research fellow in the Cancer Immunology and Immunotherapy Group, Department of Surgery at Trinit ...

Complete T Helper Cell Guide: Th1, Th2, Th17 & Functions - Your Ultimate Resource from Assay GenieIn this guide, we will explore the differences between TH1 and TH2 cells, their cruc ...

Introduction T lymphocytes are type of white blood cell that plays a crucial role in the immune system. There are many different types of T cells, and it is important to be able to di ...

Glucocorticoid-induced tumor necrosis factor receptor (GITR) is an immune checkpoint molecule that plays a crucial role in regulating T cell activation and survival. In recent years, GIT ...

window.SHOGUN_IMAGE_V2_ELEMENTS = window.SHOGUN_IMAGE_V2_ELEMENTS || new Array(); window.SHOGUN_IMAGE_V2_ELEMENTS.push({ uuid: 's-19118a5d-7dea-4fc9-8267-6237960845ca' }) The T ...

Fluorescence Resonance Energy Transfer (FRET) assays represent a pivotal technique in the molecular and cellular biology fields, enabling the examination of protein interactions, nucleic acid str ...

By Charlotte O'Donnell PhD ...

What You Need to Know About PrezalumabWhat is Prezalumab?Prezalumab is a monoclonal antibody designed to target CD47, a protein often overexpressed in cancer cells to evade immune detec ...

The Spanish flu pandemic of 1918-1919 was the deadliest in history. It is estimated that up to 100 million people died from the virus, which is more than three times the number who ...

Written by Seán Mac Fhearraigh, PhD  •  Updated: 19 May 2026  •  ~9 min read Quick Answer ELISA and Western Blot are both antibody-based protein detection methods. ELISA is f ...

Quick Facts About LacnotuzumabWhat is Lacnotuzumab?Lacnotuzumab is a monoclonal antibody targeting CD47, a protein that helps cancer cells evade immune system destruction.What is the me ...

Platelet activation plays a pivotal role in hemostasis, the process that stops bleeding and initiates tissue repair after vascular injury. This complex biological mechanism involves the transform ...

Platelet adhesion is a critical process in the maintenance of hemostasis, the body's response to bleeding. This intricate process involves a series of interactions between platelets, the cellular ...

Introduction to FoxP3 and Regulatory T Cells in CancerFoxP3 (forkhead box P3) is a transcription factor critical for the development and function of regulatory T cells (Tregs), a special ...

Delve into the myeloid lineage, a cornerstone of the immune system and blood cell production, understanding its vital roles and implications in health and disease. Key Takeaways: Myelo ...

What is preeclampsia? According to the World Health Organization (WHO), one in ten pregnant women is affected by hypertensive disorders, and preeclampsia ...

Microglial Functions Explained: Immunity, Inflammation & NeurodegenerationKey TakewaysMicroglia are immune cells in the CNS, originating from myeloid precursor cells.They surveil th ...

This article breaks down the glycoprotein Granulocyte-macrophage colony-stimulating factor (GM-CSF) detailing its structure, function and therapeutic uses. It also describes its role in im ...

As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progression as well as biomarkers from atherosclerosis related d ...

Imagine an elite squad of soldiers sent to neutralize a hidden fortress, only to find themselves wandering aimlessly in a thick, disorienting fog just outside the gates. This is the current reality ...

Monocytes, as part of the innate immune system, act as the first line of defense against foreign invaders. One of their primary functions is phagocytosis, a crucial process in which they engul ...

Quick Facts About VesencumabWhat is Vesencumab?Vesencumab is an experimental monoclonal antibody designed to target CD47, a key regulator of immune evasion in cancer cells.How Does Vese ...

Quick Facts About TigatuzumabWhat is Tigatuzumab?Tigatuzumab is a monoclonal antibody that targets the death receptor 5 (DR5) pathway, inducing apoptosis in cancer cells.What is the mec ...

Only 1% of our blood is made up of white blood cells, but they have a significant impact. Alternatively referred to as leukocytes, white blood cells. We are shielded from disease an ...

Quick Facts About EmapalumabWhat is Emapalumab?Emapalumab is a fully human monoclonal antibody that neutralizes interferon-gamma (IFN-γ). It is the first FDA-approved therapy for primar ...

Quick Facts About PlonmarlimabWhat is Plonmarlimab?Plonmarlimab is a monoclonal antibody targeting GM-CSF, a cytokine involved in inflammation and immune responses.How does Plonmarlimab ...

ILC2 - Function, Cytokines, and Role in Health and Disease A quick guide to IL2C ...

Quick Facts About LitifilimabWhat is Litifilimab?Litifilimab is a monoclonal antibody developed by Biogen targeting BDCA2, a receptor on plasmacytoid dendritic cells (pDCs), to regulate ...

Quick Facts About BegelomabWhat is Begelomab?Begelomab is a monoclonal antibody that targets CD26, a key molecule involved in immune regulation. It has been studied for its potential ap ...

Quick Facts About IcrucumabWhat is Icrucumab?Icrucumab is a monoclonal antibody that targets vascular endothelial growth factor receptor-1 (VEGFR-1) to inhibit tumor angiogenesis.How Do ...

In the realm of immunology, the terms "immunoglobulin" and "antibody" often find themselves used interchangeably, sparking confusion among those keen on understanding the immune system's fine det ...

In the realm of biomedical imaging, the quest for precision and clarity drives researchers to explore innovative technologies. One such breakthrough is the Cy3 wavelength, a powerful tool revo ...

Western blotting is a powerful and widely used technique in molecular biology, essential for detecting and quantifying specific proteins in complex biological samples. However, despite its pop ...

The STING (Stimulator of Interferon Genes) pathway plays a pivotal role in the innate immune system's response to cancerous cells and DNA viruses. Exploiting this pathway through STING activators ...

The selection of a secondary antibody is a critical step in the experimental design of various immunodetection methods, including Western Blot, ELISA, immunohistochemistry (IHC), and immunofluore ...

Quick Facts About UliledlimabWhat is Uliledlimab?Uliledlimab is a monoclonal antibody targeting CD47, a checkpoint protein that helps tumors evade immune system detection. By blocking C ...

by Ryan Wallis, PhD Aging and Disease Imagine a world where everything you do is missing just a little piece and as time goes on you start to lose sense entirely. This is the dev ...

Our Cancer Research Club symposium series continued on Wednesday afternoon, at Royal College of Surgeons (RCSI), Dublin, Ireland. The Bouchier-Hayes lecture theatre was at maximum capacity ...

{ "@context" : "http://schema.org", "@type" : "Article", "name" : "Glucose Uptake Assay Kits", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, ...

Lab PostersScientific & Inspirational Posters for Your LabEnhance your lab environment with Assay Genie's exclusive collection of scientific and inspirational posters. Designed to motiva ...

High Sensitivity Cytokine ELISA Cytokine ELISA Kits & Multiplex ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-38a43 ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-6747133c-26 ...

document.addEventListener("DOMContentLoaded",(function(){var e=document.querySelector(".page-sidebar");e&&e.remove(),document.querySelectorAll(".page-heading").forEach((function(e){e.re ...