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    ​TNF alpha & Inflammation(Post)

    Immunology · Cytokine SignallingTNF-alpha and Inflammation: Structure, Signalling & TherapyTumour necrosis factor alpha (TNF-α) is one of the most important pro-inflammatory cytokines in the body ...

    TNF cytokines and their Receptors(Post)

    The human body is a complex and intricate system where various components work together to maintain health and combat potential threats. Among these essential players are the TNF cy ...

    TNFRSF9: Enhancing Immune Cell Activity Against Tumors(Post)

    Introduction to TNFRSF9 and Its Role in Immune ActivationTNFRSF9, also known as 4-1BB or CD137, is a co-stimulatory receptor expressed on the surface of T cells, natural killer (NK) cell ...

    TNFR2: Taming Regulatory T Cells to Enhance Anti-Tumor Immunity(Post)

    In recent years, cancer immunotherapy has become a powerful tool for treating various malignancies. One promising approach involves targeting the tumor microenvironment, particularly reg ...

    How to Thaw Cells: Best Practices for Cell Culture Success(Post)

    Cell culture techniques are fundamental to biomedical research, providing crucial insights into cellular functions, drug discovery, and disease mechanisms. A critical step in cell culture is the ...

    Eldelumab: Unlocking the Potential of Anti-TNFSF14 in Inflammatory Diseases(Post)

    Quick Facts About EldelumabWhat is Eldelumab?Eldelumab is a monoclonal antibody targeting TNFSF14 (LIGHT), a key regulator in immune system signaling, with potential applications in inf ...

    Boiling Proteins for Western Blotting: Optimal Conditions and Best Practices(Post)

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    Cortisol and the Immune Response(Post)

    Endocrinology · ImmunologyCortisol and the Immune ResponseCortisol is the body’s primary stress hormone — a glucocorticoid released by the adrenal gland that powerfully shapes the immune system. Acti ...

    Adalimumab: Mechanism, Clinical Applications, and the Role of Biosimilars(Post)

    Quick Facts About AdalimumabWhat is Adalimumab?Adalimumab is a fully human monoclonal antibody designed to neutralize tumor necrosis factor-alpha (TNF-α), a key cytokine involved in inf ...

    Biomarkers & Inflammatory markers of atherosclerosis(Post)

    As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progression as well as biomarkers from atherosclerosis related d ...

    A Comprehensive Overview of Cell Death(Post)

    Cell death is an essential aspect of cellular biology that plays a crucial role in development, homeostasis, and disease. In this blog, we try to focus on mechanisms and various typ ...

    MAPK Signaling in Inflammatory Cytokines Pathways(Post)

    The Mitogen-Activated Protein Kinase (MAPK) pathway is a pivotal signaling cascade that plays a crucial role in mediating cellular responses to various external stimuli. This pathway is intricate ...

    Dendritic Cells - Markers, Activation & Subtypes(Post)

    Exploring the multifaceted role of dendritic cells in immune function and disease. Key Takeaways DCs are professional antigen-presenting cells that capture, process, and pres ...

    T Helper Cells: Th1, Th2, Th17 Differences & Functions [2026](Post)

    Complete T Helper Cell Guide: Th1, Th2, Th17 & Functions - Your Ultimate Resource from Assay GenieIn this guide, we will explore the differences between TH1 and TH2 cells, their cruc ...

    CXCL16 – Review(Post)

    CXCL16 CXCL16, a unique member of the CXC chemokine family, stands at the crossroads of immune modulation and vascular biology. Initially discovered as a che ...

    Complete T Helper Cell Guide: Th1, Th2, Th17 & Functions(Post)

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    The Rat Effectively Models Signature Cytokines of T Helper Cells(Post)

    Understanding the immune system's intricacies requires models that accurately reflect its complexity. The rat, as a model organism, plays a crucial role in immunological research, particularly i ...

    Chemokines versus Cytokines: A Detailed Comparative Study(Post)

    The complex interplay between chemokines and cytokines is fundamental to the immune system's function, orchestrating the body's response to infection, inflammation, and injury. This detailed anal ...

    Secukinumab: A Comprehensive Guide to Its Mechanism, Applications, and Biosimilar Advancements(Post)

    Quick Facts About SecukinumabWhat is SecukinumabSecukinumab is a monoclonal antibody that targets interleukin-17A (IL-17A), a key cytokine involved in inflammatory and autoimmune respon ...

    Biosimilar: Expanding Access to Monoclonal Antibody-Based Therapies(Post)

    1. What is a Biosimilar? A biosimilar is a biologic medical product that is highly similar to an already-approved reference biologic. While minor differences in clinically inactive ...

    EGF Family (Post)

    Epidermal Growth Factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor epidermal growth factor receptor (EGFR) which triggers ligand-induced ...

    TLR4: Unraveling the Role of Inflammation in Cancer Progression(Post)

    Introduction to TLR4 and Cancer Toll-like receptor 4 (TLR4) is a key component of the innate immune system, primarily responsible for detecting infections and initiating inflammator ...

    Adhesion molecules in atherosclerosis – ICAM1(Post)

    Adhesion Molecules Direct cell-cell interactions are maintained and regulated by cell adhesion molecules. The expression of adhesion molecule ...

    Neuroimmunology: The Immune System of the CNS(Post)

    What is Neuroimmunology? Neuroimmunology is a multidisciplinary scientific field dedicated to investigating the intricate and bidirectional interactions between the ...

    Gut Inflammation and Inflammatory Diseases (Post)

    What is Gut Inflammation? The gut, or gastrointestinal (GI) tract is a long tube that starts from the mouth and extends to the anus. It includes various organs suc ...

    What is CAR T-cell therapy?(Post)

    CAR T-cell therapy CAR (Chimeric Antigen Receptor) T-cell Therapy is a type of cancer treatment. CAR T-cells are made in the laboratory and they have an artificially created receptor on th ...

    Cytokine Storms: What happens when the immune system overreacts?(Post)

    Discover the critical role of cytokines as signaling molecules in immune responses, their functions, and the impact of their dysregulation, including cytokine storms. Key Takeaways: C ...

    An Overview of the glycoprotein GM-CSF(Post)

    This article breaks down the glycoprotein Granulocyte-macrophage colony-stimulating factor (GM-CSF) detailing its structure, function and therapeutic uses. It also describes its role in im ...

    Necrosis: Types, Causes, Symptoms & Prevention [2026 Guide](Post)

    What is Necrosis? Necrosis is a pathological process characterized by the death of cells or tissues within a living organism. It occurs as a result of various factors, including injury, inf ...

    Auto-inflammatory diseases and genetics (SAIDs)(Post)

    Shelly Pathak PhD candidate, University of Leeds SAIDs Systemic Auto-inflammatory diseases (SAIDs) have been defined as a group of mainly inherited disorde ...

    CD52 Expression(Post)

    What is CD52? Cluster Of Differentiation 52 (CD52) is a highly expressed membrane glycoprotein which is present on the surface of immune cel ...

    CD4+ T Cells: Unveiling the Role of Helper and Regulatory T Cells(Post)

    CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Help ...

    Anti-CTLA-4 Immunotherapy(Post)

    CD Markers Cluster of Differentiation (CD) markers play an important role in the differentiation of B cells, T cells and NK (natural killer) c ...

    Plonmarlimab: Advancing Anti-GM-CSF Therapy in Inflammatory Diseases(Post)

    Quick Facts About PlonmarlimabWhat is Plonmarlimab?Plonmarlimab is a monoclonal antibody targeting GM-CSF, a cytokine involved in inflammation and immune responses.How does Plonmarlimab ...

    NK Cells: Unlocking the Potential of Natural Killer Cells in Cancer Therapy(Post)

    Natural killer (NK) cells are a crucial component of the innate immune system and play a significant role in eliminating tumor cells. Unlike T cells, NK cells can recognize and kill canc ...

    Vorsetuzumab: Advancing Cancer Research with CD70 Targeting(Post)

    What You Need to Know About VorsetuzumabWhat is Vorsetuzumab?Vorsetuzumab is a monoclonal antibody targeting CD70, a protein found in various cancers. It shows promise for advancing can ...

    Fenofibrate Usage for Diabetes Damage(Post)

    Fenofibrate, also known as FEN, is a drug that is used to lower cholesterol levels. It works by blocking the absorption of dietary cholesterol in the small intestine and therefore, re ...

    Cyclophosphamide Side Effects(Post)

    Ovarian cancer is a set of malignancies that start in the ovaries, as well as adjacent portions of the fallopian tubes and peritoneum. Women have two ovaries, one on each side of the ...

    What Causes Acute Pancreatitis?(Post)

    Acute pancreatitis (AP) is a condition in which activated enzymes and inflammatory mediators released from the pancreas cause damage to the pancreas and surrounding tissues. AP is fur ...

    Pathological functions of IL-33/ST2 in IBD and Cancer(Post)

    By Charlotte O'Donnell PhD ...

    TIM-3: Targeting T Cell Exhaustion for Better Immunotherapy Outcomes(Post)

    T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to e ...

    Apoptosis Caspase Pathways: A Closer Look at Cellular Suicide(Post)

    Apoptosis, or programmed cell death, is a fundamental process that plays a critical role in the development and maintenance of healthy tissues. Central to this process are caspases, a family of c ...

    Macrophage, M1 & M2, Polarization and Function(Post)

    What is a Macrophage? Macrophages are indeed a type of phagocyte, responsible for engulfing and destroying foreign particles and cellular debris. They are larger cells with more cytoplasm a ...

    Types of Glial Cells(Post)

    Microglia Astrocytes Oligodendrocytes Glial ...

    CXC Chemokine Family(Post)

    In the realm of immunology, CXCL chemokines emerge as fascinating conductors. These small proteins, marked by their CXC motif, wield considerable influence over our immune responses and a r ...

    What are the stages of Parkinson's disease?(Post)

    What is Parkinson’s disease? Parkinson's disease can be seen as a neurodegenerative disease because it is associated with the loss of nerve ce ...

    Immuno-Biomaterial Development | Assay Genie(Post)

    Background I am a 3rd year PhD student in Trinity College Dublin and my project is very much an interdisciplinary one. I’m very lucky to get to work between two great labs, Dr. Aisling Dun ...

    CD31: A Comprehensive Look at an Essential Biomarker(Post)

    What is CD31? CD31, also known as PECAM-1, was originally described as a cell surface antigen present on platelets and megakaryocytes. CD31 is ...

    4-1BB: Energizing Immune Cells to Overcome Tumor Resistance(Post)

    Immunotherapy has become a central pillar in the fight against cancer, with a focus on enhancing the body’s natural defenses. Among the molecules at the forefront of immunotherapeutic re ...

    Data Science for Immunologists | Assay Genie(Post)

    By Dr. Niclas Thomas “Data science” is a recent addition to the vocabulary of analytics, and can mean many different things to different people. As f ...

    ELISA vs Western Blot: Which Technique Should You Choose?(Post)

    Written by Seán Mac Fhearraigh, PhD  •  Updated: 19 May 2026  •  ~9 min read Quick Answer ELISA and Western Blot are both antibody-based protein detection methods. ELISA is f ...

    Multiple Sclerosis and Stem Cells(Post)

    By Sonika Singh PhD candidate, University of Nottingham A Devastating Disease Multiple Sclerosis (MS) is a chronic and inflammatory disease ba ...

    Immuno Oncology: If cancer was a pathogen, would a vaccine be able to destroy it?(Post)

    Thanks to the great intuitions of brilliant scientists like Louis Pasteur, Edward Jenner, Robert Koch, Emil von Behring, Gaston Leon Ramon, Albert Sabin, Jonas Salk in the past century, the ...

    Sensing Danger: The Biology of TLR-Mediated Inflammation(Post)

    By Eoin Mac Réamoinn Toll-like receptors (TLRs) are renowned for their fundamental roles in innate sensing and initiating inflammatory responses. TLR ...

    Understanding Antibody Staining for Antigen Detection in Flow Cytometry(Post)

    Flow cytometry stands as a pivotal technique in the realms of molecular biology and immunology, enabling the analysis of physical and chemical characteristics of cells or particles as they flow i ...

    COVID-19 Biomarkers(Post)

    SARS-CoV-2 Background COVID-19 is characterised by a series of biological markers. In some instances, these biomarkers can be used as potent ...

    p38 MAPK Signaling Review(Post)

    The p38 MAPK signaling pathway is an intracellular signaling pathway that plays a crucial role in cellular responses to various stressors and inflammatory stimuli. It is a part of the larger MAPK ...

    Leukemia Inhibitory Factor (LIF)(Post)

    Leukemia Inhibitory Factor (LIF) is a cytokine that plays a crucial role in various physiological processes within the human body. It has gained significant attention in the field o ...

    Tocilizumab (Actemra®) in COVID-19 Treatment(Post)

    Tocilizumab (Actemra®) in COVID-19 Treatment What is Tocilizumab? Tocilizumab, also called atlizumab, is an immunosuppres ...

    Physiological Roles for IL-33 | Assay Genie(Post)

    By Charlotte O'Donnell PhD A role for IL-33 in Barrier Function and Epithelial Wound Healing ...

    LAG-3: Revitalizing T Cells in Exhaustion for Combination Therapies(Post)

    Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target f ...

    Etigilimab: Unveiling the Role of Anti-TIGIT in Cancer Research(Post)

    Key Facts About EtigilimabWhat is Etigilimab?Etigilimab is an anti-TIGIT monoclonal antibody being studied for its potential role in cancer immunotherapy.What role does Etigilimab play ...

    Liposomal nanosilver encapsulation for cytotoxic assays(Post)

    Nanosilver is the most commercialised nanoparticle routinely used for its antibacterial purposes in food preservation, cosmetic and health products such as medical devices and wound treatme ...

    How we can target the underlying immune processes in pathological inflammation in obesity, cancer and liver disease.(Post)

    Dr. Melissa Conroy, TTMI I am an immunologist and senior research fellow in the Cancer Immunology and Immunotherapy Group, Department of Surgery at Trinit ...

    A Quick Guide to Myelin(Post)

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    Cell Death Pathways: Intrinsic vs Extrinsic Apoptosis Guide(Post)

    At Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis! Key Takeaways: Apoptosis is a programmed cell death process, vital for tissu ...

    Iscalimab: Advancing Research in Autoimmune Diseases and Transplantation(Post)

    What You Need to Know About IscalimabWhat is Iscalimab?Iscalimab (CFZ533) is a monoclonal antibody targeting CD40, a key protein involved in immune system regulation.What is the mechani ...

    Validated GeniePlex Panels(Page)

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    GeniePlex Validated Panels by Cytometer(Page)

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    Validated Multiplex Panels by Flow Cytometer(Page)

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    NK cell activation & innate cytotoxicity(Page)

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    Adaptive immune system molecules(Page)

    Co-stimulatory and Co-inhibitory Molecules in Adaptive Immunity The adaptive immune system is in part regulated by a vast array of co-stim ...

    Non-Human Primate Multiplex ELISA Panels(Page)

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    Rat Multiplex ELISA Panels(Page)

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    ELISpot Assay Kits(Page)

    ELISpot 400x more sensitive than ELISA! Detection & Visualisation at the Single-Cell Level Explore ELISpot ...

    Adipocytokines(Page)

    Adipocytokines or adipokines are bioactive molecules that are produced by adipose tissue. They comprise cytokines, chemokines coagulation factors and factors involved ...

    GeniePlex Featured Publications(Page)

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    Cytokine neutralisation network(Page)

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    ELISA Sampler Packs(Page)

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    Top 10 Therapeutics(Page)

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    Myeloid reprogramming in the tumour microenvironment(Page)

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    CAR-T cell signalling(Page)

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    Mouse Multiplex ELISA Panels(Page)

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    Biosimilar Antibodies(Page)

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    Fast ELISA Kits(Page)

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    Proteins(Page)

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    Citations(Page)

    Product CitationsMore than 1,000 cited products in scientific journalsWe're not just any scientific company; our products have made waves in the scientific community. From groundbreaking ...

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