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Anti-Phospho-RYR2-S2814 Antibody (CABP0624)

SKU:
CABP0624
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
$155 - $587
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Phospho-RYR2-S2814 Antibody
Antibody SKU:CABP0624
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S2815 of human RYR2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:A phospho specific peptide corresponding to residues surrounding S2815 of human RYR2
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6262
Uniprot:Q92736
Cellular Location:Membrane, Multi-pass membrane protein, Sarcoplasmic reticulum membrane
Calculated MW:564kDa/565kDa
Observed MW:Refer to Figures
Synonyms:RYR2, ARVC2, ARVD2, RYR-2, RyR, VTSIP, RYR2
Background:This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.
UniProt Protein Function:RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described.
UniProt Protein Details:

Protein type:Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Transporter

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; membrane; sarcoplasmic reticulum; plasma membrane; Z disc

Molecular Function:calcium-induced calcium release activity; calmodulin binding; identical protein binding; protein binding; enzyme binding; protein self-association; calcium-release channel activity; calcium channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity

Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; positive regulation of heart rate; response to redox state; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; cellular calcium ion homeostasis; BMP signaling pathway; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction

Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia, Familial, 2

NCBI Summary:This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]
UniProt Code:Q92736
NCBI GenInfo Identifier:308153558
NCBI Gene ID:6262
NCBI Accession:Q92736.3
UniProt Secondary Accession:Q92736,Q15411, Q546N8, Q5T3P2,
UniProt Related Accession:Q92736
Molecular Weight:565kDa
NCBI Full Name:Ryanodine receptor 2
NCBI Synonym Full Names:ryanodine receptor 2 (cardiac)
NCBI Official Symbol:RYR2  
NCBI Official Synonym Symbols:RyR; ARVC2; ARVD2; RYR-2; VTSIP  
NCBI Protein Information:ryanodine receptor 2; type 2 ryanodine receptor; islet-type ryanodine receptor; kidney-type ryanodine receptor; cardiac-type ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel
UniProt Protein Name:Ryanodine receptor 2
UniProt Synonym Protein Names:Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor
Protein Family:Ryanodine receptor
UniProt Gene Name:RYR2  
UniProt Entry Name:RYR2_HUMAN
Abd Alla et al.BBLN triggers CAMK2D pathology in mice under cardiac pressure overload and potentially in unrepaired hearts with tetralogy of FallotNature Cardiovascular Research 2023View Citation

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